Author(s): V. Kamalakkannan, K.S.G. Arul Kumaran, P. Meena Prabha, R. Sambathkumar

Email(s): kamalakkannan.v@jkkn.org

DOI: 10.5958/0974-360X.2015.00160.2   

Address: V. Kamalakkannan1*, K.S.G. Arul Kumaran2, P. Meena Prabha, R. Sambathkumar 1Department of Biotechnology, Periyar Maniammai University, Thanjayur (DT), Tamilnadu, India
2Department of Pharmaceutics (H.O.D), K.M.C.H College of Pharmacy, Coimbatore-641048, Tamilnadu, India.
3Department of Pharmacognosy, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Namakka (Dt), Tamilnadu, India
4Department of Pharmaceutics (H.O.D), J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183, Namakka (Dt), Tamilnadu, India
*Corresponding Author

Published In:   Volume - 8,      Issue - 7,     Year - 2015


ABSTRACT:
Hypertension is associated with increased cardio and cerebrovascular morbidity and mortality; antihypertensive drugs have been shown to reduce the risk of adverse cardio and cerebrovascular events. These events tend to be more common during the morning hours, a time when both normo and hypertensives show a circadian peak in blood pressure (BP). Although clinicians have a number of safe and well-tolerated antihypertensive agents in various classes and formulations at their disposal, few are designed to specifically attenuate the morning BP surge while maintaining 24-h efficacy. In the treatment of hypertension, investigation of chronobiology, chronopharmacology and chronotherapy began a few decades ago. Studies over the last decade have revealed that blood pressure (BP) and CVD are influenced by our behavior such as what we eat and even conditioned by the time of day. Also, the ability of the night day ratio of systolic BP predicts the risk for cardiovascular events more accurately compared with office BP measured only at once. Evidence clearly points to the fact that nocturnal BP is indeed the BP as it is most consistently correlated with prediction of cardiovascular risk and provides more close surveillance of safety. Circadian rhythm is a significant input into the regulation of BP. Hence, a circadian disorder such as hypertension requires chronopharmacotherapy. However, different medications have been studied for their chronopharmacology and potential chronotherapy. This article reviews the chronobiology of hypertension and the chronopharmacology and chronotherapy of the Diltiazem hydrochloride used in its management.


Cite this article:
V. Kamalakkannan, K.S.G. Arul Kumaran, P. Meena Prabha, R. Sambathkumar. Chronotherapy of Cardiac Diseases using Diltiazem HCl - A Review. Research J. Pharm. and Tech. 8(7): July, 2015; Page 958-962. doi: 10.5958/0974-360X.2015.00160.2


Recomonded Articles:

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Swathy. S, Gheena. S, Sri Varsha. L

DOI: 10.5958/0974-360X.2015.00291.7         Access: Open Access Read More

Author(s): Kalaivanan S, Sarumathy S, Anisha Ebens J, Naresh Kumar K, Roobena Parveen A, Nasreen Ashraf M.

DOI: 10.5958/0974-360X.2017.00005.1         Access: Open Access Read More

Author(s): A. Chaitanya, M. Ashok Kumar, A. Gokul Krishna, P. Shanmugasundaram.

DOI: 10.5958/0974-360X.2016.00396.6         Access: Open Access Read More

Author(s): Das Biswajit, Dash Suvakanta, Choudhury Ramesh Chandra

DOI: Not Available         Access: Open Access Read More

Author(s): Roghith Kannan, Karpagam Krishnamoorthy

DOI: 10.5958/0974-360X.2016.00242.0         Access: Open Access Read More

Author(s): Santosh G Shep, Ashish B Roge, Nikhil M Mahajan, Atish R Sawant, Rupesh S Kamble, AV Chandewar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags