Author(s): Lalit Kumar1, BS Suhas, Girish Pai K1, Ruchi Verma*

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Address: Department of Pharmaceutical Chemistry, Department of Pharmaceutics1, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar – 576 104, Manipal, Udupi, Karnataka, India.

Published In:   Volume - 8,      Issue - 7,     Year - 2015

Solubility of the drug plays a crucial role in the formulation and development of the drug. Assessing the solubility of the drug is one of the most important parameter in pre-formulation. Parenteral formulations require sufficient solubility of the drug molecules. Correspondingly bioavailability from solid formulations like tablets and capsules is also dependent on solubility and permeability. The objective of this study was to investigate the solubility of drug in different pH medium using UV visible spectrophotometer. The drug solubility was studied in the pH range 1.2 to 7.4. This study concludes that the naproxen has pH dependent solubility.

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