M. S. Palled, A. R. Bhat, A. Patel
M. S. Palled*, A. R. Bhat, A. Patel
Department of Pharmaceutical Chemistry, K.L.E.S’s College of Pharmacy, KLE University Belagavi, 590 010, Karnataka, India.
Volume - 8,
Issue - 6,
Year - 2015
Tuberculosis is a disease that has been known from the earliest of recorded history. The development of the multidrug-resistant TB (Mtb) strains, treatment of active TB is more complicated than it used to be. Therefore, there is an urgent need for the development of novel anti-tuberculosis drugs, which will be active against both drug-sensitive and drug-resistant Mtb strains. FtsZ (Filamental temperature-sensitive protein Z), a tubulin homolog, is the most critical protein for bacterial cell division. GTP dependent polymerization of FtsZ forms a dynamic helical structure at the center of the cell called Z-ring. Recruitment of other cell division proteins leads to the contraction of Z-ring, which initiates the cell division. Therefore, novel molecules, which interfere polymeriza¬tion or depolymerization of FtsZ can be developed as anti-tuberculosis agents. It has been found that the treat¬ment of MTB with albendazole and thiabendazole, known tubulin inhibitors, leads to the cell filamentation, indicative of FtsZ inhibition. Accordingly, we designed and synthesized a library of benzimida¬zoles to investigate their microbacterial activities. A number of these compounds demonstrated substantial activity against H37RV strain. We will present the synthesis and biological evaluations of these compounds.
Cite this article:
M. S. Palled, A. R. Bhat, A. Patel. Synthesis of New Series of Benzimidazole Acetic Acid Derivatives Bearing Thiophene Moiety for Anti-Tubercular Activity. Research J. Pharm. and Tech. 8(6): June, 2015; Page 674-678. doi: 10.5958/0974-360X.2015.00106.7