Author(s): Karam A. El-Sharkawy, Mohammed M. A. El-Brrati, Ibrahim A. Ghardaly, Maksood Ali

Email(s): karamsyn@yahoo.com

DOI: 10.5958/0974-360X.2015.00087.6   

Address: Karam A. El-Sharkawy1,2*, Mohammed M. A. El-Brrati,1 Ibrahim A. Ghardaly,3 and Maksood Ali4
1Pharmaceutical Chemistry Department, Pharmacy Collage, Jazan University. Jazan City, Kingdom of Saudi Arabia.
2Chemistry Department, Faculty of Biotechnology, October University for Modern Sciences and Arts(MSA), El-Wahat Road, 6 October City, Egypt.
3Poison Control and Medical Forensic Chemistry Center, Jazan Health, Jazan City, Kingdom of Saudi Arabia.
4Pharmacognosy Department, Pharmacy Collage, Jazan University, Jazan City, Kingdom of Saudi Arabia.
*Corresponding Author

Published In:   Volume - 8,      Issue - 5,     Year - 2015


ABSTRACT:
The synthesis of 2-cyanomethyl-thiazole-4-one (1) was obtained via the reaction of malononitrile with thioglycolic acid, then the formed product was directed toward the reaction with either acetoacetanlide or 4-chloro acetoacetanlide to produce compounds 2, 3. The latter compounds were reacted with either aromatic aldehyde or diazonium chloride derivatives to produce compounds 10, 11, 16-21 and 28-33. Finally compound 14 and 15 were obtained through the reaction of compound 10 with either malononitrile or ethylcyanoacetate. The newly synthesized compounds were evaluated for antitumor activity.


Cite this article:
Karam A. El-Sharkawy, Mohammed M. A. El-Brrati, Ibrahim A. Ghardaly, Maksood Ali. Design and synthesis of thiazol derivatives with biological evaluations as antitumor agents. Research J. Pharm. and Tech. 8(5): May, 2015; Page 520-528. doi: 10.5958/0974-360X.2015.00087.6


Recomonded Articles:

Author(s): Pankaj Arora, M. S. Ranawat, Namita Arora

DOI: Not Available         Access: Open Access Read More

Author(s): P Janaki Pathi, P Raveendra Reddy, N Appala Raju

DOI: Not Available         Access: Open Access Read More

Author(s): J. Insira Sarbeen, Gowri Sethu

DOI: 10.5958/0974-360X.2015.00127.4         Access: Open Access Read More

Author(s): NiraimathiV, Jerad Suresh A, Kokil A.R

DOI: Not Available         Access: Open Access Read More

Author(s): Dr. Nagham Mahmood Aljamali

DOI: Not Available         Access: Closed Access Read More

Author(s): Jane Jacob, Jani Vishal M

DOI: Not Available         Access: Open Access Read More

Author(s): Karpagam T, Jannathul Firdous, Revathy, Shanmuga Priya, Varalakshmi B, Gomathi S, Geetha S, Noorzaid Muhamad

DOI: 10.5958/0974-360X.2019.00360.3         Access: Open Access Read More

Author(s): Ramesh B., Babitha S.

DOI:         Access: Open Access Read More

Author(s): M. Krishna Moorthy, Bijaya Kumar Nayak, Anima Nanda

DOI: 10.5958/0974-360X.2017.00790.9         Access: Open Access Read More

Author(s): Nillohit Mitra Ray, Rahul Singh, Joginder Singh, Shipra Bhati, Vikas Kaushik

DOI: 10.5958/0974-360X.2020.00150.X         Access: Closed Access Read More

Author(s): K. Ishwar Bhat, Apoorva A, Abhishek Kumar, Pankaj Kumar

DOI: 10.5958/0974-360X.2019.00902.8         Access: Open Access Read More

Author(s): Sunam Saha, Kartik Kaushik, Rajat Garg

DOI: 10.5958/0974-360X.2020.00170.5         Access: Closed Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags