Author(s):
Karam A. El-Sharkawy, Mohammed M. A. El-Brrati, Ibrahim A. Ghardaly, Maksood Ali
Email(s):
karamsyn@yahoo.com
DOI:
10.5958/0974-360X.2015.00087.6 
Address:
Karam A. El-Sharkawy1,2*, Mohammed M. A. El-Brrati,1 Ibrahim A. Ghardaly,3 and
Maksood Ali4
1Pharmaceutical Chemistry Department, Pharmacy Collage, Jazan University.
Jazan City, Kingdom of Saudi Arabia.
2Chemistry Department, Faculty of Biotechnology, October University for Modern Sciences and Arts(MSA), El-Wahat Road, 6 October City, Egypt.
3Poison Control and Medical Forensic Chemistry Center, Jazan Health, Jazan City, Kingdom of Saudi Arabia.
4Pharmacognosy Department, Pharmacy Collage, Jazan University, Jazan City, Kingdom of Saudi Arabia.
*Corresponding Author
Published In:
Volume - 8,
Issue - 5,
Year - 2015
ABSTRACT:
The synthesis of 2-cyanomethyl-thiazole-4-one (1) was obtained via the reaction of malononitrile with thioglycolic acid, then the formed product was directed toward the reaction with either acetoacetanlide or 4-chloro acetoacetanlide to produce compounds 2, 3. The latter compounds were reacted with either aromatic aldehyde or diazonium chloride derivatives to produce compounds 10, 11, 16-21 and 28-33. Finally compound 14 and 15 were obtained through the reaction of compound 10 with either malononitrile or ethylcyanoacetate. The newly synthesized compounds were evaluated for antitumor activity.
Cite this article:
Karam A. El-Sharkawy, Mohammed M. A. El-Brrati, Ibrahim A. Ghardaly, Maksood Ali. Design and synthesis of thiazol derivatives with biological evaluations as antitumor agents. Research J. Pharm. and Tech. 8(5): May, 2015; Page 520-528. doi: 10.5958/0974-360X.2015.00087.6
Cite(Electronic):
Karam A. El-Sharkawy, Mohammed M. A. El-Brrati, Ibrahim A. Ghardaly, Maksood Ali. Design and synthesis of thiazol derivatives with biological evaluations as antitumor agents. Research J. Pharm. and Tech. 8(5): May, 2015; Page 520-528. doi: 10.5958/0974-360X.2015.00087.6 Available on: https://rjptonline.org/AbstractView.aspx?PID=2015-8-5-16