Author(s): Rajan V. Rele

Email(s): drvinraj@gmail.com

DOI: 10.5958/0974-360X.2015.00072.4   

Address: Rajan V. Rele*
Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016.
*Corresponding Author

Published In:   Volume - 8,      Issue - 4,     Year - 2015


ABSTRACT:
The objective of the study was to develop a simple, accurate, precise and rapid a UV spectrophotometric i.e. second order derivative method for the determination of ambroxal hydrochloride and salbutamol sulphate in combined dosage form i.e. tablets by using distilled water as a solvent. The method was further validated by ICH guidelines. The proposed second order derivative method involves the measurement of absorbance of one drug at zero crossing point of other; hence wavelengths 221.1 nm and 236.4 nm were selected for the estimation of ambroxal hydrochloride and salbutamol sulphate respectively. The linearity of the proposed method was found in the concentration range of 1 to 10 µg /ml (r2= 0.9989) for ambroxal hydrochloride and 1 to 14 µg /ml (r2= 0.9981) for salbutamol sulphate respectively. The percentage mean recovery was found to be 100.813 % for ambroxal hydrochloride and 100.065 % for salbutamol sulphate respectively. The method was also statistically validated for its linearity, accuracy and precision. Both intra and inter day variations showed less percentage (%) RSD values indicating high grade of precision of this method.


Cite this article:
Rajan V. Rele. Simultaneous Spectrophotometric Estimation of Ambroxal Hydrochloride and Salbutamol Sulphate by Second Order Derivative Method in Combined Dosage Form. Research J. Pharm. and Tech. 8(4): April, 2015; Page 432-436. doi: 10.5958/0974-360X.2015.00072.4


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DOI: 10.5958/0974-360X 

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