Author(s): K. Girija, B. Jamuna

Email(s): girijanarasimhan66@gmail.com

DOI: 10.5958/0974-360X.2015.00069.4   

Address: Dr. K. Girija*, B. Jamuna
Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-06, India.
*Corresponding Author

Published In:   Volume - 8,      Issue - 4,     Year - 2015


ABSTRACT:
A growing threat of resistance to antibiotics by various microorganisms, an attempt has been made to identify the potent Aryl imidazole derivatives for its antimicrobial activities. A series of Aryl imidazole derivatives were synthesized by the condensation of various primary aromatic amines with aromatic aldehyde to form respective schiff’s base which on further undergone reaction with ammonium acetate and Isatin in presence of glacial acetic acid to form the title compounds. The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR and 13C-NMR spectral studies. Based on AutoDock score, the potent aryl imidazole derivatives were selected for their Antimicrobial study. The screened compounds showed moderate to good antibacterial activity against Staphylococcus aureus, Bacillus cereus, E.coli, Salmonella typhi when compared to standard (Ciprofloxacin-30mcg/disc). In the antifungal study among the screened compounds, JG3 only showed moderate antifungal activity against Candida albicans when compared to standard (Clotrimazole-30mcg).


Cite this article:
K. Girija, B. Jamuna. Design and Synthesis of Some Novel Schiff’s Base Aryl Imidazole Derivatives, Characterization, Docking and Study of their Anti-Microbial Activity. Research J. Pharm. and Tech. 8(4): April, 2015; Page 407-415. doi: 10.5958/0974-360X.2015.00069.4


Recomonded Articles:

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Amutha K*, Ashok Kumar A, Godavari A

DOI: 10.5958/0974-360X.2017.00100.7         Access: Open Access Read More

Author(s): Pooja Thakur, Chirag Chopra, Daljeet Singh Dhanjal, Reena Singh Chopra

DOI: 10.5958/0974-360X.2017.00466.8         Access: Open Access Read More

Author(s): Sajid Ali, Maryam Shabbir, Nabeel Shahid

DOI: 10.5958/0974-360X.2015.00019.0         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Author(s): Pankaj Kumar, Jennifer Fernandes, Abhishek Kumar

DOI: 10.5958/0974-360X.2017.00023.3         Access: Open Access Read More

Author(s): Sandeep DS, Narayana Charyulu R, Prashant Nayak, Aliss Maharjan, Indira Ghalan

DOI: 10.5958/0974-360X.2016.00163.3         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Nada Khazal Kadhim Hindi, Iman Fadhil Abdul-Husin, Zainab Khudhur Ahmad Al-Mahdi, Ruqaya M. J. Ewadh, Ahmed Obaid Hossain, Mohanad Jawad Kadhim, Ali Hussein F. Alnasraui, Amean A. Al-Yaseri

DOI: 10.5958/0974-360X.2017.00343.2         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): K.V. Swathi

DOI: 10.5958/0974-360X.2016.00239.0         Access: Open Access Read More

Author(s): Kulkarni Anup, Kale Mohan, Sarode Suraj, Firke Sandip, Firke Bhushan, Warke Prashant

DOI: Not Available         Access: Open Access Read More

Author(s): Saba Shaikh, Ravi Dubey, Swati Dhande, Y.M Joshi, Vilasrao J. Kadam

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags