Author(s): Swarnalatha. Y

Email(s): lokiswarna@gmail.com

DOI: 10.5958/0974-360X.2015.00077.3   

Address: Swarnalatha. Y*
Department of Biotechnology, Sathyabama University, Jeppiaar Nagar, Chennai-119.
*Corresponding Author

Published In:   Volume - 8,      Issue - 4,     Year - 2015


ABSTRACT:
Flavonoids are considered as potential explore to treat cancer and they are ubiquitous. The chemical structure and the nature of the polyphenolic flavonoids are responsible for their anticancer actions. Objective: The present investigation concentrates on the cytotoxic effect of flavonoids in A549 adenocarcinoma cell lines. Methodology: the plant extract was subjected to TLC for confirmation and HPLC confirm the pure form of the flavonoids and the induction of the cytotoxicity was studied using AO/EB, PI and the uptake of the PI was confirmed using the FACS in A549 cells. results: the TLC and HPLC results confirmed the presence of flavonoides. Flow cytometry denotes the percentage of the cells in the G0/G1 and the G2 stage. This indicates the accumulation of the cells in the apoptotic and proapoptotic stages. Conclusion: These findings indicate that the flavonoids from the Sphaeranthus amarathoides may be promising anticancer agents to control the cell growth in A549 cells.


Cite this article:
Swarnalatha. Y. Isolation of Flavonoids and their Anticancer Activity from Sphaeranthus amaranthoides in A549 Cell Line. Research J. Pharm. and Tech. 8(4): April, 2015; Page 462-467. doi: 10.5958/0974-360X.2015.00077.3


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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