Lunkad A.S., Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P.
Lunkad A.S.*, Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P.
SCSSS’s Sitabai Thite College of Pharmacy, Shirur (Ghodnadi), Dist-Pune.
Volume - 8,
Issue - 3,
Year - 2015
Benzofuran nucleus frequently occurs in natural products. In the present course of study an attempt is made for synthesis of new Benzofuran derivatives. 5-chloro-2-hydroxy acetophenone 2 was prepared by the Fries rearrangement with anhydrous aluminium chloride at 1300c for 3 hrs. The compound 2 was treated with chloroacetone in presence of anhydrous acetone and potassium carbonate gave 5-chloro-3-methyl-2-acetyl Benzofuran 3. Compound 3 underwent condensation with aromatic aldehyde and aromatic amines to furnished chalcone and Schiff derivatives 4a-e and 5a-e respectively. The synthesized compounds were screened for their antimicrobial activities.
Cite this article:
Lunkad A.S., Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P. Synthesis and Antimicrobial Activity of Some New Chalcones Containing Benzofuran and Benzofuran Schiff Bases. Research J. Pharm. and Tech. 8(3): Mar., 2015; Page 276-279. doi: 10.5958/0974-360X.2015.00046.3