Author(s): Lunkad A.S., Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P.

Email(s): amit.lunkad15@gmail.com

DOI: 10.5958/0974-360X.2015.00046.3   

Address: Lunkad A.S.*, Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P.
SCSSS’s Sitabai Thite College of Pharmacy, Shirur (Ghodnadi), Dist-Pune.
*Corresponding Author

Published In:   Volume - 8,      Issue - 3,     Year - 2015


ABSTRACT:
Benzofuran nucleus frequently occurs in natural products. In the present course of study an attempt is made for synthesis of new Benzofuran derivatives. 5-chloro-2-hydroxy acetophenone 2 was prepared by the Fries rearrangement with anhydrous aluminium chloride at 1300c for 3 hrs. The compound 2 was treated with chloroacetone in presence of anhydrous acetone and potassium carbonate gave 5-chloro-3-methyl-2-acetyl Benzofuran 3. Compound 3 underwent condensation with aromatic aldehyde and aromatic amines to furnished chalcone and Schiff derivatives 4a-e and 5a-e respectively. The synthesized compounds were screened for their antimicrobial activities.


Cite this article:
Lunkad A.S., Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P. Synthesis and Antimicrobial Activity of Some New Chalcones Containing Benzofuran and Benzofuran Schiff Bases. Research J. Pharm. and Tech. 8(3): Mar., 2015; Page 276-279. doi: 10.5958/0974-360X.2015.00046.3


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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