Amongst the various routes of drug delivery, oral route is the most preferred to the patient. However, disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract limits its use for certain drugs. Problems such as first pass metabolism and drug degradation in the harsh gastrointestinal environment can be avoided by administering drug via buccal route. The oral cavity is easily accessible for self-medication and can be promptly terminated in case of toxicity just by removing the dosage form from buccal cavity. It is also possible to administer drugs to patients who cannot be dosed orally via this route. These drug delivery systems utilize property of bioadhesion of certain water soluble polymers which become adhesive on hydration and hence can be used for targeting particular site. Buccal adhesive dosage forms are those dosage forms which can deliver drugs either locally to treat conditions within the buccal cavity or systemically via the mucosa. These drugs can be delivered via buccal route using mucoadhesive polymers as well as penetration enhancers having enzyme inhibiting activity.Both synthetic and natural polymers have been investigated extensively. The synthetic polymers have certain disadvantages such as high cost, toxicity, environmental pollution during synthesis, non-renewable sources, side effects, and poor patient compliance. However the use of natural polymers for pharmaceutical applications is attractive because they are economical, readily available, low cost, non-toxic and capable of chemical modifications, potentially biodegradable and with few exceptions and also biocompatible.
Cite this article:
Yugma B. Desai, Jitendra Singh Yadav. A Review: Bioadhesive Buccal Drug Delivery System and Its Significance. Research J. Pharm. and Tech. 8(3): Mar., 2015; Page 227-234. doi: 10.5958/0974-360X.2015.00026.8