Author(s): Mahesh HRK, K Sudhakar Babu

Email(s): hrkmahesh@gmail.com

DOI: 10.5958/0974-360X.2015.00031.1   

Address: Mahesh HRK*, Dr K Sudhakar Babu
Department of Chemistry, Sri Krishnadevaraya University, Anantapur -515055, Andhra Pradesh. India
*Corresponding Author

Published In:   Volume - 8,      Issue - 2,     Year - 2015


ABSTRACT:
A novel, rapid and a stability-indicating reverse phase LC method has been developed and validated for the simultaneous estimation of Clopidogrel and Aspirin in tablet dosage form. The chromatographic separation was achieved on a novel core shell technology phenyl hexyl stationary phase of particle size 2.6µ. The method employed a linear gradient elution and the detection wavelength was set at 220nm. The proposed method was extensively validated as per ICH guidelines. The specificity of the method was proved by performing forced degradation studies. Regression analysis shows r value (correlation coefficient) of greater than 0.999 for individual active drug substances. Accuracy was proved in the range of 50% to 150% of working range.


Cite this article:
Mahesh HRK, K Sudhakar Babu. A Novel Stability Indicating HPLC Assay Method for Simultaneous Estimation of Clopidogrel and Aspirin in Tablet dosage form by Using Core shell Technology column. Research J. Pharm. and Tech. 8(2): Feb. 2015; Page 172-176. doi: 10.5958/0974-360X.2015.00031.1


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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