Nimbalkar V.V., Pansare P.M., Nishane B.B.
Nimbalkar V.V.*, Pansare P.M., Nishane B.B.
Department of Pharmacology, P.D.V.V.P.F’s College of Pharmacy, Vilad Ghat, Post: MIDC, Ahmednagar, Maharashtra, India.414111
Volume - 8,
Issue - 12,
Year - 2015
Hepatic disease is term for a collection of conditions disease and infection that affect the cells, tissues, structure or functions of the liver. liver has a wide range of function ,including detoxification, protein synthesis , and production of biochemical necessary for digestion and synthesis as well as breakdown of small and complex, many of which are necessary for normal vital function .
Both in-vitro and in-vivo liver models have been develops in the past year two study the hepatoprotective agents. These system majors the ability of the test drug to prevent or cure liver toxicity (Induced by hepatotoxin) in experimental animals. In in-vitro model fresh hepatocytes are treated with hepatotoxin and the effect of the test drug on the same in evaluation .In in –vivo models, a toxic dose or repeated doses of a known hepatotoxinare administrated to induce liver damage in experimental animals. The test substance administrated along, with prior to and/ or after the toxin treatment. Various chemical agents normally used to induce hepatotoxicity in experimental animal for the evaluation hepatoprotective agents include carbon tetrachloride, paracetamol, Acryilamide, adrimacyin, alcohol antituburcularetc. These explain the mechanism of action of various hepatotoxic chemical drugs, their doses and routes of administration.
Cite this article:
Nimbalkar V.V., Pansare P.M., Nishane B.B. Screening Methods for Hepatoprotective Agents in Experimental Animals. Research J. Pharm. and Tech. 8(12): Dec., 2015; Page 1725-1732. doi: 10.5958/0974-360X.2015.00310.8