Author(s): Narayan P. Firke1, Anil G. Markandeya1, Rajendra Patil2, Haribhau M. Gholap3, Rajendra S. Konde Deshmukh1, Shirish S. Pingale4*

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Address: 1Department of Chemistry, Fergusson College, Pune 411 004 India 2Department of Biotechnology, University of Pune, Ganeshkhind, Pune 411 007 India 3Department of Physics, Fergusson College, Pune 411 004 India 4Department of Chemistry, ACS College, Narayangaon, Pune 410 504 India

Published In:   Volume - 8,      Issue - 1,     Year - 2015


ABSTRACT:
In present study, we report synthesis of Betulinan C and its analogs and explore its biological application as an agent inhibiting the biofilm formation in Pseudomonas aeruginosa O1. P. aeruginosa biofilm is prominently inhibited 80-83% by compounds 2a and 1b at 25 g/mL. While other analogs show a mixed response. Biofilm inhibition is further confirmed by Scanning Electron Microscopy. The present study is important as Betulinan C has been produced by a fungus of order Chaetothyriales and there are no chemical methods yet reported for its synthesis. The inhibition of biofilm is due to inhibition of quorum sensing (QS) phenomenon. Contrary to the traditional bioactive molecules, QS phenomenon is not essential for the survival of cells, and therefore, present compounds will not create a selection pressure of antibiotics resistance in cells on which they act.


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RNI: CHHENG00387/33/1/2008-TC                     
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