Author(s): Suraj B, C D Tripathi, Krishna Biswas, B M Padhy, Tarun Arora

Email(s): drsurajpanchal@gmail.com

DOI: 10.5958/0974-360X.2015.00009.8   

Address: Dr. Suraj B1*, Dr. C D Tripathi2, Dr. Krishna Biswas3, Dr. B M Padhy4, Dr. Tarun Arora5
1Department of Pharmacology, ESIC Medical College, Gulbarga, 585106, India
2Department of Pharmacology, VMMC & Safdarjung Hospital, New Delhi, 110029, India
3Department of Endocrinology, VMMC & Safdarjung Hospital, New Delhi, 110029, India
4Department of Pharmacology, AIIMS, Bhubaneswar, Orissa, 751019, India
5Department of Pharmacology, LHMC, New Delhi, 110001, India
*Corresponding Author

Published In:   Volume - 8,      Issue - 1,     Year - 2015


ABSTRACT:
Background and objectives: Type 2 diabetes mellitus (T2DM) is progressive multisystem disease requiring multiple antihyperglycaemic agents to attain or maintain glycaemic control. With the increase in incidence of T2DM and availability of a number of drugs as second line therapy there is considerable increase in the use of newer, more costly oral hypoglycaemic agents, which has resulted in substantial increase in associated costs to patients. The present study was aimed to evaluate the safety, efficacy and cost effectiveness of oral antidiabetic regimens. Methods: This study was an observational, prospective and longitudinal in nature carried out to study the safety, efficacy and cost effectiveness of three add on treatment regimens [i.e with sulfonylurea (group 1), glitazones (group 2) and dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) (group 3)] in patient with T2DM not controlled by metformin alone which included 150 subjects (approximately 50 patient in each group). The comparisons were conducted between these three groups for glycosylated haemoglobin (HbA1c), fasting plasma glucose (FPG), post prandial glucose (PPG), costs and lipid profile. Results: At week 12, the significant reduction in HbA1c was found in group 1 (-1.19%) when compared to group 2 (-0.71%) and group 3 (-0.70%). Also significantly greater reductions were observed in group 1 in FPG level (-38.88%) when compared to group 3 and in PPG level (-54.08%) when compared to group 2 and group 3. Comparison of three groups showed significant increase in the cost in group 3 as compared to group 1 and group 2, with the highest cost effectiveness measured in group 1 (p<0.0001). Interpretation and conclusions: Group 1 resulted in significantly greater reductions in HbA1c, FPG and PPG levels and highest cost effectiveness when compared with group 2 and group 3 in patients with T2DM.


Cite this article:
Suraj B, C D Tripathi, Krishna Biswas, B M Padhy, Tarun Arora. Research J. Pharm. and Tech. 8(1): Jan. 2015; Page 44-50. doi: 10.5958/0974-360X.2015.00009.8


Recomonded Articles:

Author(s): Santhosh Kumar V, Praveen D

DOI: 10.5958/0974-360X.2016.00123.2         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Vaddi Mounika, S. Sarumathy, J. Anisha Ebens, T. S. Shanmugarajan

DOI: 10.5958/0974-360X.2017.00003.8         Access: Open Access Read More

Author(s): Kalaivanan S, Sarumathy S, Anisha Ebens J, Naresh Kumar K, Roobena Parveen A, Nasreen Ashraf M.

DOI: 10.5958/0974-360X.2017.00005.1         Access: Open Access Read More

Author(s): Fatemeh Haidari, Esmat Mansoori, Mehrnoosh Zakerkish, Mohammadhossein Haghighizadeh

DOI: 10.5958/0974-360X.2017.00263.3         Access: Open Access Read More

Author(s): R. Pandian , Lalitha Kumari

DOI: 10.5958/0974-360X.2016.00471.6         Access: Open Access Read More

Author(s): Aravind R., Bindu A.R., Bindu K., Alexeyena V.

DOI: Not Available         Access: Open Access Read More

Author(s): Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP, Baheti DR

DOI: Not Available         Access: Open Access Read More

Author(s): B Srivastava, Uttam Singh Baghel, Pradeep Swarnkar and Shuchi Dave

DOI: Not Available         Access: Open Access Read More

Author(s): Dhananjay Sangle, Amit Naik, Amol Ghorpade, Vikram Ghatkar, Suvarna Ghuge, Dipti Ingle, Rishikesh Ingle

DOI: Not Available         Access: Open Access Read More

Author(s): Suganya M, Yadavi Soondron, Mahadeva Rao US.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags