Author(s): Jane J., Mani Prasad

Email(s): janempharm@gmail.com

DOI: Not Available

Address: Jane J.*, Mani Prasad
Associate Professor, Dept. of Pharma. Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte-575018, Mangalore
*Corresponding Author

Published In:   Volume - 7,      Issue - 9,     Year - 2014


ABSTRACT:
Metoprolol and Telmisartan is a multicomponent dosage form belonging to the class of antihypertensives. The main aim of the study was to develop economical simple, rapid, accurate , precise, sensitive and reliable for their routine analysis. Two methods were developed. A simultaneous estimation of metoprolol and telmisartan by UV spectrophotometry, secondly by RP-HPLC. Method 1 was estimated by three multicomponent analysis procedure, in method 1a the estimation of Metoprolol and Telmisartan was based on Simultaneous equation analysis for metoprolol and telmisartan by UV absorption at 276nm and 296nm respectively and linearity was observed in the concentration range of 20-100 microgram /mL for both the drugs. Method 1b, simultaneous estimation by Q-analysis based on isoabsorptive point(269 nm) and at 296 nm. Method 1c, was absorption correction method were the linearity was observed between 20-100 microgram/ml at their respective absorption maximas. Method 2 involved an isocratic elution of Metoprolol and Telmisartan in a column of phenomenex C18,250x4.6,5 microusing a mobile phase of composition acetonitrile and ammonium acetate buffer of pH 3.5 in the ratio 70:30 v/v at a flow rate of 1ml/min and the analyte was monitored at 269nm. The chromatograms of the standard and dosage forms of metoprolol and telmisartan were recorded and linearity was observed in the concentration range of 30-70 microgram/ml and 24-56 microgramg/ml respectively. All the developed methods were extended to formulations.Various degradation studies like acid, base, oxidative and thermal degradation were carried out. All the methods were validated based on ICH guidelines and were found to be simple reliable and the results are reproducible.


Cite this article:
Jane J., Mani Prasad. Simultaneous Estimation of Metoprolol and Telmisartan Dosage Form. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 1020-1024.


Recomonded Articles:

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Malarkodi Velraj, P. Jasmine Shiney, Biplab Paul, Rashmi. S, Nivethitha

DOI: 10.5958/0974-360X.2017.00006.3         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): S. Poongothai, C.M. Karrunakaran, R. Ilavarasan

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags