Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

Email(s): moresandesh7@gmail.com

DOI: Not Available

Address: Sandesh More1*, Javed Mirza2 , Nanasaheb Kale3, Mayur Gandhi4, Rakesh Chaudhari5
1Department of Pharmaceutics, M.G.V. College of Pharmacy, Panchavati, Nashik-422003, Maharashtra, India.
2Department of Quality Assurance Techniques, M.V.P. Samaj’s College of Pharmacy, Near K.T.H.M. Campus, Gangapur road, Nashik-422002, Maharashtra, India.
3Department of Pharmaceutical Chemistry, M.V.P. Samaj’s College of Pharmacy, Near K.T.H.M. Campus, Gangapur road, Nashik-422002, Maharashtra, India.
4Department of Pharmaceutics, M.V.P. Samaj’s College of Pharmacy, Near K.T.H.M. Campus, Gangapur Road, Nashik-422002, Maharashtra, India.
5Department of Quality Assurance Techniques, M.V.P. Samaj’s College of Pharmacy, Near K.T.H.M. Campus, Gangapur Road, Nashik-422002, Maharashtra, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 9,     Year - 2014


ABSTRACT:
The purpose of the present research work was to develop a robust and physicochemically stable pMDI formulation for pulmonary delivery of an Glucocorticoide, drug-Beclomethasone. The pMDI was quickly developed, providing a reliable dose in a robust, convenient and multi-dose preparation. Fortunately, at that time, metering valves capable of developing at least 100 precise spray doses had just become available. Sprays from pMDIs are self-propelled, the pressure of propellants inside the canister being used to force the spray out of the pressure of propellants inside the canister being used to force the spray out of the device via a narrow nozzle in the plastic actuator.Beclometasone dipropionate is a pro-drug with weak glucocorticoid receptor binding affinity. It is extensively hydrolysed via esterase enzymes to the active metabolite beclometasone-17 monopropionate (B-17-MP), which has potent topical anti-inflammatory activity. Formulation contains Anhydrous Beclometasone Dipropionate (Micronised) , Ethanol , Oleic Acid , HFA 134a(1,1,1,2 Tetrafluoro Ethane), HFA 227ea (1,1,1,2,3,3,3- Heptafluoro Propane) , Propylene Glycol , PEG 300, PEG 1000, Povidone K-25. formulation was evaluated for fine particle dose, mass median aerodynamic diameter, uniformity of dose, leak test, water content, net content, no of doses. Hence it was concluded that pressurised based MDI formulation in an attempt to develop pulmonary administrable product of Beclomethasone was found to be stable and robust with desired attributes of packaging requirements.


Cite this article:
Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari. Formulation and Development of a “Pressurised Metered Dose Inhalation” beclomethasone 250 mcg.. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 963-967.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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