Author(s): Mayur V. Chinchore, Pankaj D. Kothawade, Rajendra K. Surwase, Avish D. Maru

Email(s): mayur.chinchore55@gmail.com

DOI: Not Available

Address: Mayur V. Chinchore*, Pankaj D. Kothawade, Rajendra K. Surwase, Avish D. Maru
Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal- Kalwan, Dist- Nashik (423501), Maharashtra, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 8,     Year - 2014


ABSTRACT:
Amlodipine is widely used in the treatment of Hypertension, Angina pectoris and Cardiac arrhythmia. The present study is deals with formulation, optimization evaluation of Amlodipine sublingual films. Hypertension, Angina pectoris and Cardiac arrhythmia are the conditions where instance effect of drug is required. Amlodipine is one of the drug which is used in the treatment of above three disease conditions. The sublingual films was prepared by using solvent casting method. The concentration of polyvinyl alcohol (PVA), glycerin, sodium lauryl sulphate (SLS) were kept constant in all formulations (F1-F9) and varying concentration of hydroxy propyl methyl cellulose(HPMC). All the formulations were evaluated for surface pH, weight uniformity, folding endurance, drug content, disintegration time, in-vitro dissolution studies. The formulation ‘F5’ was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 90.10±0.16 mg, surface pH 6.75±0.60, folding endurance > 100, drug content 98.60±0.60%, disintegration time 17±0.30 sec, and in-vitro dissolution study 98.78 % at the end of 5 min.


Cite this article:
Mayur V. Chinchore, Pankaj D. Kothawade, Rajendra K. Surwase, Avish D. Maru. Formulation, Optimization and Evaluation of Amlodipine Besylate Sublingual Films. Research J. Pharm. and Tech. 7(8): August 2014 Page 840-844.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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