Author(s): B. Siddartha, Sudheer Babu, C. Parthiban, Prathyusha V.

Email(s): siddarthabethi@rediffmail.com

DOI: Not Available

Address: B. Siddartha1*, Dr. I. Sudheer Babu2, C. Parthiban1, Prathyusha V.1
1Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, Secunderabad
2Sir C.R. Reddy College of Pharmaceutical Sciences, Eluru.
*Corresponding Author

Published In:   Volume - 7,      Issue - 4,     Year - 2014


ABSTRACT:
A simple, precise and accurate UV Spectrophotometric method has been developed for estimation of Tinidazole in bulk and tablet dosage form. In this method Tinidazole shows Lyamda max at 365nm using 0.1N NaOH as a solvent. The responses were linear in the range of 5-25 microgram/ml. The regression equation of the calibration graph and correlation coefficient were found to be y = 0.039x + 0.008 and 0.999 respectively. The recovery of the drug from the sample was ranged between 99.09% and 99.23%. The proposed method was validated as per ICH Q2 (R1) guidelines for precision, linearity, accuracy and recovery. The %RSD values for both intraday and interday precision were less than 1%. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.034 microgram/ml and 0.103 microgram/ml respectively by simple UV spectroscopy.


Cite this article:
B. Siddartha, Sudheer Babu, C. Parthiban, Prathyusha V. Method Development and Method Validation of Tinidazole in Bulk and Pharmaceutical Dosage Form by UV– Spectrophotometric Method. Research J. Pharm. and Tech. 7(4): April, 2014; Page 467-469.

Cite(Electronic):
B. Siddartha, Sudheer Babu, C. Parthiban, Prathyusha V. Method Development and Method Validation of Tinidazole in Bulk and Pharmaceutical Dosage Form by UV– Spectrophotometric Method. Research J. Pharm. and Tech. 7(4): April, 2014; Page 467-469.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2014-7-4-7


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DOI: 10.5958/0974-360X 

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