Author(s): K. Vijaya Sri, G.Vinay Jain, M. Maduri

Email(s): vijayasree_2002@yahoo.co.in

DOI: Not Available

Address: K. Vijaya Sri*, G. Vinay Jain and M. Maduri
Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad-500 014, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 4,     Year - 2014


ABSTRACT:
The main objective was to develop and validate the UV-spectrophotometric method for the estimation of rilpivirine hydrochloride in bulk and pharmaceutical formulations as per ICH guidelines. The initial stock solution of rilpivirine hydrochloride was prepared in methanol solvent and subsequent dilution were done in 0.1NHCL. The Lambda max of rilpivirine hydrochloride was found to be 280 nm it was proved linearity in the concentration range 0.25–3 microgram/ml with a correlation coefficient value of 0.999. The accuracy studies of proposed method was performed at three different levels, i.e., 50%, 100%, and 150% and recovery was found to be in the range of 100.4%. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.33and 1.26 µg/ml, respectively. The % RSD less than 2 which indicates the accuracy and precise of the method. The above method was a rapid tool for routine analysis of rilpivirine hydrochloride in the bulk and in the pharmaceutical dosage form.


Cite this article:
K. Vijaya Sri, G.Vinay Jain, M. Maduri. UV Spectrophotometric Method for the Estimation of Rilpivirine in Bulk and Pharmaceutical Formulations. Research J. Pharm. and Tech. 7(4): April, 2014; Page 463-466.


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