Author(s): Ujwala R. Bagmar, Dinesh C. Sancheti, Sarika R. Zade, Varsha K. Pawar, Nanda R. Badhe

Email(s): ubagmar@gmail.com

DOI: Not Available

Address: Ujwala R. Bagmar*, Dinesh C. Sancheti, Sarika R. Zade, Varsha K. Pawar, Nanda R. Badhe
SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2014


ABSTRACT:
The purpose of this study was to prepare and evaluate a taste-masked drotaverine hydrochloride fast disintegrating tablet to prevent bitter taste of the drug and for increase in drug release. The drug was characterized according to different compendial methods, on the basis of identification by UV spectroscopy, IR, organoleptic properties and other tests. Taste masking was performed by coating drotaverine hydrochloride with polyvinyl pyrrolidone (PVP) using a solvent evaporation technique. Among the different ratios of drug:polymer,1:1 was selected for further studies because of high drug loading capacity (75%) and good mouth feel effect. The granules of optimized drug-polymer complexes (DPCs) were tested for packing and flow properties. These granules were compressed into tablets and evaluated for hardness, friability, drug content, wetting time, in vitro disintegration time and in vitro taste in simulated salivary fluid (SSF) of pH 6.2. The Superdisintegrant CCS (crosscarmellose sodium) and crospovidone were used for immediate release of drug from tablet. The granules of the optimized DPCs were free flowing with angle of repose<300. These tablets disintegrated rapidly (<68sec) with a wetting time of 24sec. It also showed rapid drug release in stimulated gastric fluid (SGF) within 6 min up to 92%. This study shows the suitability of PVP polymers SSG, CCS superdisintegrant in masking the bitter taste and rapid release of drotaverine HCl.


Cite this article:
Ujwala R. Bagmar, Dinesh C. Sancheti, Sarika R. Zade, Varsha K. Pawar, Nanda R. Badhe. Design and Evaluation of Fast Disintegrating Tablets of Taste-Masked Drotaverine Hydrochloride Using Polyvinyl Pyrrolidone. Research J. Pharm. and Tech. 7(3): Mar., 2014; Page 301-306.


Recomonded Articles:

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Dhanalekshmi UnniKrishnan Nair, MP Saraswathy, Narra Kishore, Neelakanta Reddy Pully

DOI: Not Available         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): T. Arunkumar, Ann Feba Ebby, G. Narendrakumar

DOI: 10.5958/0974-360X.2017.00441.3         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Shrivastava Alankar, Jain R., Agrawal R.K., Ahirwar D.

DOI:         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Md Kamal Hossain, Kamrun Nahar, Parisa Shokryazdan, Norhani Abdullah, Kaiser Hamid, Mohammed Faseleh Jahromi

DOI: 10.5958/0974-360X.2017.00530.3         Access: Open Access Read More

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Author(s): Aravind R., Bindu A.R., Bindu K., Alexeyena V.

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Priti Patel, Ashok Kumar P., Hemil Shah, Nikunj Patel, Pratik Kheni, Someshwara Rao B., Suresh V. Kulkarni, Babitha S.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags