Jaybhaye Aarti, Joshi Sonali, Deshmukh Ganesh
Jaybhaye Aarti*, Joshi Sonali, Deshmukh Ganesh
Oriental College of Pharmacy, Plot No. 3, 4,5, Sector-2, Sanpada, Navi Mumbai-400705
Volume - 7,
Issue - 3,
Year - 2014
Oral drug delivery remains the most preferred route for administration of various therapeutic agents. Recent advances in technology prompted researchers and scientists to develop orodispersible tablets (ODTs) with improved patient convenience and compliance. ODTs are solid unit dosage form which dissolve or disintegrate rapidly in the mouth without water or chewing. Over the past three decades, orodispersible tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance, improved solubility and stability profiles. New ODT technologies address many pharmaceutical and patient needs, ranging from enhanced life-cycle management to dosing for pediatric, geriatric, and psychiatric patients with dysphasia (difficulty in swallowing). This has encouraged both academia and industry to generate new orally disintegrating formulations and technological approaches in this field. The aim of this article is to review the development of ODTs, challenges in formulation, superdisintegrants employed, new ODT technologies and evaluation methodologies, suitability of drug candidates, and future prospects.
Cite this article:
Jaybhaye Aarti, Joshi Sonali, Deshmukh Ganesh. Orodispersible Tablets: A Comprehensive Review. Research J. Pharm. and Tech. 7(3): Mar., 2014; Page 368-375.