Author(s): Masthanamma S.K., Pradeepthi, Jahnavi

Email(s): masthanamma.sk@gmail.com

DOI: Not Available

Address: Masthanamma S.K.*, Pradeepthi, Jahnavi
Department of Pharmaceutical Analysis, Acharya Nagarjuna University ,Nagarjuna Nagar, Guntur District, Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2014


ABSTRACT:
A simple, fast, accurate and precise reverse phase HPLC method was developed for the separation and quantification of Azilsartan medoxomil in pharmaceutical dosage form. The quantification was carried out using Hypersil BDSC18, 250X4.6 mm, 5µ, enhanced polar selectivity column and mobile phase comprised of potassium dihydrogen phosphate buffer pH adjusted to 4.0 ± 0.5 with orthophosphoric acid and acetonitrile in proportion of ratio 60:40 and degassed under ultrasonication. The flow rate was 1.0mL/min and the effluent was monitored at 248nm. The retention time of Azilsartan medoxomil was 3.8 min .The method was validated in terms of linearity, precision, accuracy, specificity, limit of detection and limit of quantitation as per ICH guide lines. Linearity ofAzilsartan was in the range of 10-60 microgram/mL .The percentage recovery of azilsartan is 99.8% from the tablet formulation.The present method is used for routine quality control of the Azilsartan medoxomil. and in tablet dosage form.


Cite this article:
Masthanamma S.K., Pradeepthi, Jahnavi. Stability Indicating RP-HPLC Method for Determination of Azilsartan Medoxomil in Pharmaceutical Dosage Form. Research J. Pharm. and Tech. 7(2): Feb. 2014; Page 168-172.


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Mostafa Isbera, Ayat Abbood, Wehad Ibrahim

DOI: 10.5958/0974-360X.2016.00039.1         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags