The aim of present investigation was to increase dissolution rate of Nabumetone by solid dispersion technique and it is incorporated into the gel. All formulations were prepared by Kneading method and subsequently characterized and evaluated for drug release, interaction study by FT-IR, X-ray diffraction study, and DSC study from this study following points are concluded. A present study demonstrates the Kneading technique was successful for preparation of Nabumetone solid dispersion using PEG 4000, PEG 6000 and Poloxamer 188.The increased dissolution of Nabumetone with increase in the molar ratio of polymer. Amongst all batches of solid dispersion batch F9 showed Drug content 95.24±1.03 percentage drug release 92.53±0.7 within 1 Hour. FT-IR analysis suggest the intactness of the drug in the formulations. Results of XRD and DSC confirmed amorphous formation and their stabilization. preparation of solid dispersion of Nabumetone optimized and batch was incorporated into the gel. The prepared formulations were transparent opaque in appearance with Carbopol 940.The drug content, pH, Extrudability and Spreadability was found within acceptable range.The viscosity of gel was increased as concentration of gelling agent increased.The optimum concentration of gelling agent for Carbopol 940 (0.8%w/w) was found to be good.Amongst all batches of Gel batch A2 showed Drug content 93.14±0.86 percentage drug release from diffusion study 95.68±0.59 within 1 Hour It is helpful for to improve the patient compliance toward the management of pain & inflammation topically and it overcome gastric side effect of drug.Stability study showed that the Gel formulation was stable and there is no significant change in physical properties and drug content.
Cite this article:
Suvidha Suryakant Patil, Shriniwas Krishna Mohite. Development and Evaluation of Solid Dispersion Incorporated Topical Gel of Nabumetone. Research J. Pharm. and Tech. 7(12): Dec. 2014; Page 1413-1419.