Author(s): S. Poongothai, C.M. Karrunakaran, R. Ilavarasan

Email(s): poongothai.sun@gmail.com

DOI: Not Available

Address: S. Poongothai1* C.M. Karrunakaran2 and R. Ilavarasan3
1Bharath University, Selaiyur, Chennai-600 073, India
2SMK Fomra Institute of Technology, Chennai - 603 103, India
3Captain Srinivasa Murthi Drug Research Institute for Ayurvedha and Siddha, Arumbakkam, Chennai-600 106
*Corresponding Author

Published In:   Volume - 7,      Issue - 11,     Year - 2014


ABSTRACT:
The aim of this work is to develop and validate a dissolution test for ropinirole tablets based on in vivo data. The best dissolution conditions were USP apparatus 1, 500 ml of medium containing pH 4.0 deaerated citrate buffer at a speed of 50 rpm and detection was carried at 250 nm. The in vitro dissolution samples were analyzed and validated using HPLC method according to USP protocol. The method showed accuracy, precision, linearity and specificity within the acceptable range. The kinetics of dissolution was determined using model-dependent methods. The dissolution profiles were best described by Hixson–Crowell model.


Cite this article:
S. Poongothai, C.M. Karrunakaran, R. Ilavarasan. Development and Validation of a Discriminating Method of Dissolution for Ropinirole Tablets Based on In Vivo Data. Research J. Pharm. and Tech. 7(11): Nov. 2014 Page 1285-1291.


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