Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Formulation and Evaluation of Colon Targeted Drug Delivery System of Mesalamine Using Wet Granulation

Author(s): Ashish Y. Pawar, Rahul A. Ahirrao

Email(s): rahulahirrao14@gmail.com

DOI: Not Available

Address: Ashish Y. Pawar, Rahul A. Ahirrao*
M.G.V’S Pharmacy College, Panchavati, Nashik- 422003. India
*Corresponding Author

Published In:   Volume - 7,      Issue - 11,     Year - 2014

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ABSTRACT:
Mesalamine is Anti-inflammatory drug used for the treatment of inflammation of bowel i.e. ulcerative colitis and chron’s disease. In the present study an attempt is made to formulate colon targeted drug delivery system of mesalamine using Eudragit S100 and HPMC K100 as a release retarding polymers. Various formulations were developed by varying concentration of Eudragit S100 and HPMC K100 by using wet granulation technique. The developed formulation were coated using thin layer of Eudragit S100 as a pH dependent polymer which starts to dissolves above pH 7 and releases drug at the site of action and protects the tablet from releasing drug in stomach and intestine. The 3² factorial design were used to formulate various formulations of Mesalamine. Developed formulation were evaluated for various parameters like hardness, friability etc. The formulation F9 was found to be optimum based on all evaluation parameters. Also the optimized formulation is found to be stable for 3 months and doesn’t change its colour, shape, release pattern.


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Cite this article:
Ashish Y. Pawar, Rahul A. Ahirrao. Formulation and Evaluation of Colon Targeted Drug Delivery System of Mesalamine Using Wet Granulation. Research J. Pharm. and Tech. 7(11): Nov. 2014 Page 1270-1279.

Cite(Electronic):
Ashish Y. Pawar, Rahul A. Ahirrao. Formulation and Evaluation of Colon Targeted Drug Delivery System of Mesalamine Using Wet Granulation. Research J. Pharm. and Tech. 7(11): Nov. 2014 Page 1270-1279.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2014-7-11-3


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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