Author(s): Aarti P. Nikam, Mukesh. P. Ratnaparkhi

Email(s): artipawar.pharma@gmail.com

DOI: Not Available

Address: Aarti P. Nikam*, Prof. Mukesh. P. Ratnaparkhi
Marathwada Mitra Mandal’s College of Pharmacy, University of Pune, Thergaon Pune-33 India
*Corresponding Author

Published In:   Volume - 7,      Issue - 11,     Year - 2014


ABSTRACT:
The objective of this study was to develop the Losartan potassium sustained release tablets. This can be achieved by formulating tablets by direct compression method, by employing semi-synthetic and natural polymers like HPMCK100M, Carbopol 934 and Xanthan gum in various concentrations. The powdered blend evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The results obtained were satisfactory. Compressed formulations were further evaluated for thickness, friability, and hardness, swelling index and in-vitro dissolution studies. All the formulations showed good results, which were in compliance with Pharmacopoeia standards. A response surface methodology was used to select the optimized formulation wherein types of polymer and concentration of polymer were taken as independent variables and amount of drug release was taken as dependent variables. Optimization studies were carried out by using the Design Expert software version 8.0.1. The in vitro drug release followed Zero Order model and the drug release mechanism was found to be Non-Fickian type.


Cite this article:
Aarti P. Nikam, Mukesh. P. Ratnaparkhi. Formulation and Evaluation of Losartan Potassium Sustained Release tablets. Research J. Pharm. and Tech. 7(11): Nov. 2014 Page 1219-1225.


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Amina Mehrin Bano, Vishnupriya. V, Gayathri. R

DOI: 10.5958/0974-360X.2016.00171.2         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags