Author(s): Gaddam Rajendra Prasad, S. Indira, Nalini Shastri, Mamidi Sadanandam

Email(s): prasadmpharm@gmail.com

DOI: Not Available

Address: Gaddam Rajendra Prasad*, S. Indira, Nalini Shastri, Mamidi Sadanandam
Sri Venkateshwara College of Pharmacy, Madhapur, Hyderabad, Andhra Pradesh- 509001, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 1,     Year - 2014


ABSTRACT:
Cefixime is a third generation cephalosporin with broad spectrum of activity. The present investigation highlights the formulation and optimization of floating tablets of cefixime. Cefixime floating tablets were prepared by effervescent technique employing two different grades of Methocel (Methocel K4M and Methocel K15M) and a natural polymer Psyllium Husk. Sodium bicarbonate was incorporated as a gas generating agent. The floating tablets were evaluated for tablet hardness, friability, assay of drug, in vitro buoyancy and in vitro dissolution studies. The prepared tablets exhibited satisfactory physico chemical characteristics. All the prepared batches showed in vitro buoyancy. It was observed that the tablet remained buoyant for 12 hours. Increase in the sodium bicarbonate level decreases the floating lag time but tablets floated longer duration. The drug release from the tablets was followed diffusion controlled release and release profiles were best explained by Higuchi equation. Formulation F3, F8, FP5 showed better controlled drug release and in vitro buoyancy.


Cite this article:
Gaddam Rajendra Prasad, S. Indira, Nalini Shastri, Mamidi Sadanandam. Formulation and In-Vitro Evaluation of Cefixime Gastroretentive Drug Delivery System. Research J. Pharm. and Tech. 7(1): Jan. 2014; Page 29-33.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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