Author(s): Girish Pai K, M. Sreenivasa Reddy

Email(s): girish.pai@manipal.edu

DOI: Not Available

Address: Girish Pai K* and M. Sreenivasa Reddy
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 1,     Year - 2014


ABSTRACT:
Objective of this research was to formulate and evaluate extended release ocular inserts/ films of anti-conjunctival drug, Sodium Cromoglycate. Novel natural polymer namely, Pullulan and synthetic polymer namely, Hydroxy Ethyl Cellulose (HEC) were used as biodegradable, biocompatible polymers. Standardized glass mould was used to prepare ocular inserts. The ocular inserts were prepared with constant drug content and 10% concentration of polymer. The aim was to maintain the thickness of ocular insert at not more than 0.40 mm. Ocular inserts were prepared using Pullulan 10% and HEC 10%. Formulated ocular inserts were evaluated for parameters like appearance, thickness, weight variation and uniformity of drug content. For in vitro studies, In-House (IH) vial method was used to determine the rate of dissolution using phosphate buffer saline (pH 7.4). Ocular inserts prepared from both polymers showed differences with respect to physical properties such as appearance, weight and thickness. Films of both the polymers showed differences with respect to physico-chemical properties such as appearance, weight and thickness. The films were smooth, thin, soft and pliable. Appearance of Pullulan 10% films was almost clear to slightly opaque whereas films of HEC 10% were slightly off white in color. The Pullulan 10% films had average thickness of 0.21mm and films of HEC 10% had average thickness of 0.19mm.The average weights of Pullulan 10% films were 10.8 mg whereas average weight of HEC 10% films was found to be 14.8 mg. The drug content of Pullulan 10% film and HEC 10% film was confirming to limits. The in vitro release study was carried out using phosphate buffer saline of pH 7.4. Both the films dissolved completely over a period of time. Pullulan 10% films showed in vitro release for 3 hours whereas HEC 10% films showed in vitro release for 6 hours. However, since the thickness of Pullulan 10% films are well within required specification of less than 0.40 mm, further studies shall be carried out with Pullulan by increasing the concentration and shall then evaluated for thickness and in vitro release studies. We assume that higher concentration of Pullulan films can extend the drug release for few more hours thus yielding promising result.


Cite this article:
Girish Pai K, M. Sreenivasa Reddy. Formulation and Evaluation of Extended Release Ocular Inserts prepared from Synthetic and Natural Biodegradable - Biocompatible Polymers. Research J. Pharm. and Tech. 7(1): Jan. 2014; Page 48-51.


Recomonded Articles:

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Chandak BG, Sarpate RV, Chatterjee NR, Baheti KG

DOI: Not Available         Access: Open Access Read More

Author(s): S Hemalatha and M Jegadeesan

DOI: Not Available         Access: Closed Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Vijay Simha G.1, Meena Ajay Kumar1, Sannd Rajesh1, Panda P.2 and M.M. Rao3

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi Kumar, Jismon Jose, Mahin M.M., Rahul Raut, Shantesh Masurkar, Narayana Swamy V.B.

DOI: Not Available         Access: Open Access Read More

Author(s): Sushil J. Pawar, Santosh Y. Nandedkar, Rajendra D. Wagh, Tanvir Shaikh, Vaibhav Jagtap

DOI: Not Available         Access: Open Access Read More

Author(s): Sumit Yadav, Kawtikwar PS, Sakarkar DM, Gholse YN, Ghajbhiye SD

DOI:         Access: Open Access Read More

Author(s): Karthikeyan D., Sonkar S., Pandey V.P., Nandha kumar J., Sengottuvelu S., Bhowmick M., Shivakumar T.

DOI:         Access: Open Access Read More

Author(s): Akansha Bhandarkar, Amit Alexander, Aditi Bhatt, Pankaj Sahu, Palak Agrawal, Tripti Banjare, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Hemlata Thapa, Deepika, Vinay Sagar Verma, Mukesh Sharma, D. K. Tripathi, Ajazuddin

DOI: 10.5958/0974-360X.2018.00243.3         Access: Open Access Read More

Author(s): P.K. Upadhyay, Vikas Kumar Jain, Kavita Sharma, Ravi Sharma

DOI: 10.5958/0974-360X.2020.00297.8         Access: Closed Access Read More

Author(s): C. Das, A. Mohanty, S. Dash, D.C. Sahoo, N.S.K. Choudhury, V.J. Patro, S.K. Kanungo

DOI:         Access: Open Access Read More

Author(s): Sarvade Dattatray D., Harisha C. R., Shukla Vinay. J., Acharya Rabinarayan

DOI: 10.5958/0974-360X.2020.00134.1         Access: Closed Access Read More

Author(s): Girish Pai K., Baldha Parinkumar Dhirajlal

DOI: Not Available         Access: Open Access Read More

Author(s): Suko Hardjono, Tri Widiandani, Bambang T. Purwanto, Anindi L. Nasyanka

DOI: 10.5958/0974-360X.2019.00359.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags