Author(s): CH. Prasanthi, N.L. Prasanthi, K. Deepika

Email(s): prasanthi.mpharm@gmail.com

DOI: Not Available

Address: CH. Prasanthi*, N.L. Prasanthi, K. Deepika
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, A.P, India- 522034.
*Corresponding Author

Published In:   Volume - 6,      Issue - 9,     Year - 2013


ABSTRACT:
The objective of the present study is to formulation and evaluation of the floating drug delivery system of Nizatidine. Floating tablets of Nizatidine (150mg) were formulated by employing HPMC K100M, Chitosan and Carbopol940 as matrix former at 50% strength, sodium bicarbonate and calcium carbonate at 15% and 10% strength as gas generating agent respectively. The polymers Carbopol940 and Chitosan were combined with HPMCK100M in different ratios to control release rate of drug. The drug-excipient compatibility, pre and post compression parameters, buoyancy properties and swelling index were evaluated. The results of the in vitro release studies showed that the matrix polymer HPMCK100M (HF) release the drug more controlled manner than Chitosan and Carbopol940. The formulation NF5 (Chitosan: HPMC-20:80%) release the drug similar to HF. The formulations (SF4, SF5) containing combination of HPMCK100M and Carbopol940 release the drug more controlled manner than HF.


Cite this article:
CH. Prasanthi, N.L. Prasanthi, K. Deepika. Formulation and Evaluation of Nizatidine Floating Tablets by using Natural, Semisynthetic and Synthetic Polymers. Research J. Pharm. and Tech. 6(9): September 2013; Page 1032-1036.


Recomonded Articles:

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Gupalli Laxmi Narasimha, Dappu Jairam, Akkenapally Krishna, Mohammed Rehan Qureshi

DOI: 10.5958/0974-360X.2015.00025.6         Access: Open Access Read More

Author(s): K. Gnanaprakash, K.B. Chandhra Shekhar, C. Madhu Sudhana Chetty

DOI: Not Available         Access: Open Access Read More

Author(s): M.A. Saleem, Raghavendra V. Kulkurni, Patil Noornadim G

DOI: Not Available         Access: Open Access Read More

Author(s): Saleem M.A., Sudhir S. Pange, Shaikh Ahnaf Umair, Vishal Kumar Singh

DOI: Not Available         Access: Open Access Read More

Author(s): Thulasi V. Menon, C.I. Sajeeth

DOI: Not Available         Access: Open Access Read More

Author(s): Pavani M., D.P. Mastan Yadav, Manikanta Kumar A., K.S. Manjunath Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Pare A, Yadav SK, Patil UK

DOI:         Access: Open Access Read More

Author(s): S.S. Manikiran, S.N.H. Pratap, N.L. Prasanthi, N. Ramarao

DOI: Not Available         Access: Open Access Read More

Author(s): Akelesh T., Sam Johnson, Udaya Chander J., Subhojit Samantha, Venkatanarayanan R.

DOI: 10.5958/0974-360X.2015.00268.1         Access: Open Access Read More

Author(s): Akbari BV, Dholakiya RB, Shiyani BG, Lodhiya DJ

DOI: Not Available         Access: Open Access Read More

Author(s): G.V. Wadageri, S.A. Raju, S.B. Shirsand, P. Vijay Prakash Reddy

DOI: Not Available         Access: Open Access Read More

Author(s): Satyabrata bhanja, K. Lakshmi Deepthi, Muvvala Sudhakar, Bibhuti Bhusan Panigrahi

DOI: Not Available         Access: Open Access Read More

Author(s): K.B. Koteshwara, Anup Naha, Bishu Choubey

DOI: Not Available         Access: Open Access Read More

Author(s): Nitin Chandrakant Mohire, Adhikrao Vyankatrao Yadav, Vaishali Kondibhau Gaikwad

DOI:         Access: Open Access Read More

Author(s): Karthikeyan D., Sonkar S., Pandey V.P., Nandha kumar J., Sengottuvelu S., Bhowmick M., Shivakumar T.

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags