ABSTRACT:
Solubilization of poorly soluble drugs is a frequently encountered challenge in screening studies of new chemical entities as well as in formulation design and development. Solubility of some drugs is very less; these drug molecules are often lipophilic and hence dissolution may be a problem in drug absorption from solid oral dosage forms. The increasing interest of the technology of dosage form with natural biopolymers has become the reason for undertaking present investigation on the possibility of modification of guar gum application in the preparation of an oral solid dosage form of a poorly water soluble drug. Present study examines the effect of modified guar gum on the solubility of a poorly water-soluble Nevirapine. Modified guar gum was prepared using heat treatment (110-120oC for 2 hours) method. It was characterized for viscosity and swelling index etc. The physical and co-grinding mixtures of Nevirapine with modified guar gum were prepared in 1:4 drugs to gum ratio. The physical and co-grinding mixtures were characterized by DSC and FT-IR study. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The results of present investigation indicated that modified guar gum can be a used for the development of oral dosage form with increased solubility and hence improved dissolution and oral bioavailability of poorly water soluble drug.