Manoj M Nitalikar, Dinesh M. Sakarkar
Manoj M Nitalikar1*, Dinesh M. Sakarkar2
1Research Scholar, Department of Pharmaceutical sciences, Suresh Gyan Vihar University,
2Department of Pharmaceutics, Sudhakarrao Naik Institute of Pharmacy, Pusad, Dist. Yavatmal, (India)
Volume - 6,
Issue - 7,
Year - 2013
Skin delivery of NSAIDs offers several advantages over the oral route associated with potential side effects. The present research has been undertaken with the aim to develop a topical gel formulation of Meloxicam, which would attenuate the gastrointestinal relater toxicities associated with oral administration. Meloxicam is a nonsteroidal anti-inflammatory drug. It has anti-inflammatory, analgesic and antipyretic activity through inhibition of prostaglandinsynthetase, via inhibition of cyclooxygenase enzymes. This study was designed to enhance the solubility of Meloxicam by preparing its inclusion complex with Beta-cyclodextrin and formulating gels using Carbopol 940 and HPMC E 6. The gels were evaluated for release through goat abdominal skin. It was observed that the formulation containing complex (DCG 2) was good in all respects.
Cite this article:
Manoj M Nitalikar, Dinesh M. Sakarkar. Formulation and evaluation of topical gel of Meloxicam with Beta-Cyclodextrin complex. Research J. Pharm. and Tech 6(7): July 2013; Page 790-793.