A. K. Patel, Raj K. Prasad, S. S. Gautam, Omprakash
A. K. Patel1*, Raj K. Prasad1, S. S. Gautam1, Omprakash2
1Shambhunath Institute of Pharmacy, Jhalwa, Near IIIT, Allahabad, U.P., India-211012
2R. K. G. Institute of Pharmacy, Gaziabad, U. P., India
Volume - 6,
Issue - 6,
Year - 2013
The purpose of this study was to develop formulations and systematically evaluate in vitro performances of super porous hydrogel composites of Metoprolol Tartrate. A cross-over design was employed in formulating the SPHC with variation in polymer concentration (N, N-methylene-bisacrylamide (1-3%) and Ac-Di-Sol (200-300mg)). Study the effect of variation on swelling time, mechanical properties and in vitro drug release. The result shows that increase in Ac-Di-Sol concentration also increase in mechanical strength where as 2% of Bis concentration have less swelling time. In-vitro release data show that best result at optimum concentration of Bis (2%) and Ac-Di-Sol concentration (250mg).
Cite this article:
A. K. Patel, Raj K. Prasad, S. S. Gautam, Omprakash. Formulation and Evaluation of Super Porous Hydrogel Composites of Metoprolol Tartrate. Research J. Pharm. and Tech 6(6): June 2013; Page655-658.