Author(s): Shinde Sunita S., Amol S. Shete, Patil Manisha V., J.I. Disouza

Email(s): sunithashinde@gmail.com

DOI: Not Available

Address: Shinde Sunita S.1*, Amol S. Shete2 Patil Manisha V.1, J.I. Disouza1
1Department of Pharmaceutics, Tatayasaheb Kore College of Pharmacy, Warananagar
2Department of Pharmacognosy, Ashokrao Mane College of Pharmacy, Pethvadgaon, Ambap
*Corresponding Author

Published In:   Volume - 6,      Issue - 6,     Year - 2013


ABSTRACT:
The purpose of this research work to prepare a sustained release tablet of Theophylline. by direct compression method. Different hydrophilic polymers like hydroxypropyl methyl cellulose and xanthan gum were used. The effects of polymers concentration on drug release profile were investigated. Cumulative % release of drug for 1st hour and 8th hour were studied In formulation Theophylline Sustained Release tablet, direct compression employed for preparation of tablets possessing optimized characteristics (batches B3to B5). The amount of HPMC and Xanthan gum were calculated and selected for optimize batch. Results of the present study confirmed that the hydrophilic polymers and hardness plays a major role in drug release. As the hydrophilic polymers and hardness of the tablets increased the drug release was prolonged.


Cite this article:
Shinde Sunita S., Amol S. Shete, Patil Manisha V., J.I. Disouza. Formulation and Evaluation of Sustained Release Tablets using Direct Compression Method. Research J. Pharm. and Tech 6(6): June 2013; Page 637-640.

Cite(Electronic):
Shinde Sunita S., Amol S. Shete, Patil Manisha V., J.I. Disouza. Formulation and Evaluation of Sustained Release Tablets using Direct Compression Method. Research J. Pharm. and Tech 6(6): June 2013; Page 637-640.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2013-6-6-20


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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