Asadul Mazid Helali, Zaida Rahman, Rukhsana Amin, Rabeya Yousuf, Arefuddin Ahmed, Abdus Salam, Mainul Haque
Asadul Mazid Helali1, Zaida Rahman2, Rukhsana Amin3, Rabeya Yousuf4
Arefuddin Ahmed5, Abdus Salam6, Mainul Haque7*
1Assistant Professor, Department of Pharmacology & Therapeutics, Gonoshasthya Samajvittik Medical College & Hospital, Dhaka.
2Associate Professor, Department of Pharmacology, Enam Medical College & Hospital, Dhaka
3Assistant Professor, Department of Pharmacology, Anwar Khan Modern Medical College, Dhaka
4Medical Officer, Blood Bank Unit, Department of Pathology, Universiti Kebangsaan Malaysia (UKM) Medical Centre, Kuala Lumpur, Malaysia.
5Senior Lecturer, Medical Radiation Programme, School of Health Sciences, Universiti Sains Malaysia
6Associate Professor, Department of Medical Education, UKM Medical Centre, Kuala Lumpur, Malaysia
7Professor, Department of Pharmacology, Universiti Sultan Zainal Abidin, Terengganu, Malaysia.
Volume - 6,
Issue - 6,
Year - 2013
Clonidine is Alfa 2 agonist antihypertensive drug but its use is limited because of multiple adverse effects including sedation. Clonidine also has effective pre-anesthetic and analgesic-properties that have been well documented in adults in different parts of the world. This drug has substantially decrease opioid or volatile anaesthetics requirements with definite improvement of cardiovascular markers. The current study was designed to investigate the efficacy of oral clonidine as pre-anaesthetic medication in reduction of post-operative pain among Bangladeshi children. This randomized, controlled trial was performed in year 2010-2011 in a private medical college in Bangladesh. A total of 60 children aged 3 months-3 years undergoing minor surgery received placebo (control) and clonidine 4 microgram/kg, 100 min before induction of anesthesia and followed by oral atropine 0.03 mg/kg, 60 minutes before anesthesia. Anaesthesia was induced and maintained with halothane and nitrous oxide with oxygen. Post-operative pain was assessed using objective pain scale (OPS). Clonidine provided lower OPS scores and reduced requirement for post-operative supplementary analgesic compared to the control. These data suggest that oral clonidine is a possible approach to facilitate post-operative analgesia in children undergoing minor surgery.
Cite this article:
Asadul Mazid Helali, Zaida Rahman, Rukhsana Amin, Rabeya Yousuf, Arefuddin Ahmed, Abdus Salam, Mainul Haque. Efficacy of Oral Clonidine as Pre-Anesthetic Medication in Reduction of Post-Operative Pain in Children- A Randomized Controlled Trial. Research J. Pharm. and Tech 6(6): June 2013; Page 632-636.