Author(s): Jane J., Dhaval Ladani

Email(s): janempharm@gmail.com

DOI: Not Available

Address: Jane J.*, Dhaval Ladani
Associate Professor, Dept of Pharma Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte-575018, Mangalore
*Corresponding Author

Published In:   Volume - 6,      Issue - 5,     Year - 2013


ABSTRACT:
Lacosamide is an anti epileptic drug, for which, two simple, sensitive, accurate, precise, and economical methods (method 1 and 2) have been developed for the quantitative estimation of Lacosamide in bulk and pharmaceutical formulation. Method-1 is a simple, accurate and sensitive HPLC method and the chromatographic separation was carried out on C8 column Welchrom (250 × 4.6mm, 5µ.) using a mobile phase composition of potassium dihydrogen phosphate buffer: acetonitrile (850:150 v/v) pumped at flow rate of 1.5 ml/min. The eluent was monitored at 215 nm with a diode array detector. Method-2 was based on condensation reaction between Lacosamide and vanillin in presence of conc. Sulphuric acid involving the formation of violet colored chromogen which showed linearity in the range 100-500µg/ml at a lambda max of 613 nm. The methods were statistically validated for precision, accuracy, robustness and recovery as per ICH guidelines


Cite this article:
Jane J., Dhaval Ladani. Development and Validation of Analytical Methods for Lacosamide. Research J. Pharm. and Tech. 6(5): May 2013; Page 553-555.


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