Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Evaluation of Antioxidant activity of Ardisia solanacea in albino rats

Author(s): Pradeep Kumar Samal

Email(s): samalpharmacology@rediffmail.com

DOI: Not Available

Address: Pradeep Kumar Samal*
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh.
*Corresponding Author

Published In:   Volume - 6,      Issue - 5,     Year - 2013

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ABSTRACT:
The objective of this study was to investigate the antioxidant activity of Ardisia solanacea leaves against carbon tetracholoride (CCl4) induced hepatotoxic model. The plant materials were dried in shade, powdered with help of hand grinder and extracted with alcohol. Preliminary phytochemical test shows the presence of Alkaloids, Carbohydrates, Tannins, Amino acids and Flavanoids. The alcoholic extract of Ardisia solanacea (AEAS) showed a significant dose dependent (100 mg and 200 mg/kg p.o.) antioxidant activity. The degree of antioxidant activity was measured by using serum biochemical parameters like hepatic antioxidant enzymes like SOD, CAT, GPX and MDA. AEAS at a dose level of 100mg/kg and 200mg/kg produce significant (P<0.001) antioxidant activity by decreasing the level Malondialdehyde, while it significantly increased the levels of Glutathione peroxidise (GPX), superoxide dismutase (SOD) and Catalase activity (CAT) in a dose dependent manner. The effect of AEAS was comparable to that of standard drug Silymarin.


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Cite this article:
Pradeep Kumar Samal. Evaluation of Antioxidant activity of Ardisia solanacea in albino rats. Research J. Pharm. and Tech. 6(5): May 2013; Page 585-588.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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