Author(s): Sheeja Velayudhan Kutty, Greeshma S., Vidhya P.M., D. K. Sunith

Email(s): greeshmasivarajan@gmail.com

DOI: Not Available

Address: Mrs. Sheeja Velayudhan Kutty, Greeshma S.*, Vidhya P.M., Mr. D. K. Sunith
Department of Pharmaceutical Analysis, Grace College of Pharmacy, Kodunthirapully Post, Palakkad, Kerala, India, Pin 678004
Grace College of Pharmacy, Palakkad, Kerala
Cresent College of Pharmaceutical Sciences, Kannur, Kerala
*Corresponding Author

Published In:   Volume - 6,      Issue - 4,     Year - 2013


ABSTRACT:
A simple, sensitive, precise and accurate UV-Visible spectrophotometric method has been developed for the determination of Risperidone in bulk drug and pharmaceutical formulation (tablet). The method is based on the oxidative coupling reaction of the drug with 3-Methyl-2-Benzthiazolinone hydrochloride (MBTH) in the presence of Ferric chloride Fe (III) to form green coloured chromogen exhibiting Lambda max at 666nm. Beer’s law was obeyed over the concentration range of 4-14µg/ml with a linear regression value 0.993.The method was validated in accordance with the current ICH guidelines. Interday and Intraday studies showed high degree of repeatability, recoveries obtained do not differ significantly from 100% showed accuracy and reliability of the method. The proposed method was applied successfully for the determination of Risperidone in pure bulk form and in tablets without interference from commonly encountered additives.


Cite this article:
Sheeja Velayudhan Kutty, Greeshma S., Vidhya P.M., D. K. Sunith. Development and Validation of Spectrophotometric Method for the Determination of Risperidone in pure and Pharmaceutical Formulation using MBTH reagent. Research J. Pharm. and Tech. 6(4): April 2013; Page 388-391.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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