Author(s): Kaniz Fatima Urmi, Ashraf Uddin Chowdhury, Farhana Diba, Khandaker Ashfaqur Rahman, Razibul Habib, Kaiser Hamid

Email(s): kaiserpharm_1134@yahoo.com

DOI: Not Available

Address: Kaniz Fatima Urmi1, Md. Ashraf Uddin Chowdhury2, Farhana Diba3, Khandaker Ashfaqur Rahman1, Md. Razibul Habib3, Kaiser Hamid3*
1Department of Pharmacy, Jahangirnagar University, Bangladesh
2International Islamic University Chittagong, Bangladesh
3Department of Pharmacy, East West University, Bangladesh
*Corresponding Author

Published In:   Volume - 6,      Issue - 4,     Year - 2013


ABSTRACT:
The present study was carried out to assess the cytotoxic and antioxidant activities of methanol, ethyl acetate and n-hexane extract of leaves of Aegle marmelos or Bael. The cytotoxicity assay was carried out by brine shrimp lethality bioassay. The antioxidant properties were assessed by using 1, 1-diphenyl-2- picrylhydrazyl radical (DPPH) and nitric oxide (NO) scavenging capacity. The methanol, ethyl acetate and n-hexane extracts showed potential antioxidant activity with IC50 values of 6.629, 4.383 and 3.606 µg/ml respectively and comparison was made with standard ascorbic acid having IC50 value of 2.687µg/ml. The methanol extract depicted potential antioxidant activity with IC50 value of 1.233µg/ml in nitric oxide scavenging capacity assay compared to standard ascorbic acid of 3.712µg/ml. The extracts showed potent cytotoxic activity with LC50 values of 4.482, 5.278 and 5.278 µg/ml respectively whereas the standard vincristine sulfate showed 3.364µg/ml. The three extracts of leaves of A. marmelos possessed significant antioxidant and cytotoxic potentials in this experiment


Cite this article:
Kaniz Fatima Urmi, Ashraf Uddin Chowdhury, Farhana Diba, Khandaker Ashfaqur Rahman, Razibul Habib, Kaiser Hamid. Evaluation of Antioxidant and Cytotoxic Potential of Different Extracts from the Leaves of Aegle marmelos L. Research J. Pharm. and Tech. 6(4): April 2013; Page 384-387.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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