The objective of present study was to develop diclofenac sodium organogel using sorbitan monoesters. Various organogels were prepared using isopropyl myristate, tween 80, sorbitan monostearate and sorbitan monopalmitate as organogelator. The formulated organogels were evaluated for their appearance, homogeneity, pH, viscosity, spreadibility, and % drug content and drug release. The drug release study was carried out using Franz diffusion cell.Rat skin of suitable size was clamped on to the cell. Organogel containing 7.5% of sorbitan monostearate showed highest drug release rate, however on further increasing the organogelator concentration the drug release rate was found to decrease. This decrease in drug release rate can be attributed to entrapment of drug into fiber network which hinder drug release. Organogel containing sorbitan monopalmiatate showed a lower drug release rate
Cite this article:
Bhagyashree Purohit, Naveen Gupta, Shailesh Jain. Formulation and Evaluation of Diclofenac sodium Organogel. Research J. Pharm. and Tech. 6(4): April 2013; Page 375-378.