Author(s): Naimish A. Sarkhejiya, Krupraj K. Khachar, Vipul P. Patel

Email(s): naimishpatel2019@gmail.com

DOI: Not Available

Address: Naimish A. Sarkhejiya*, Krupraj K. Khachar, Vipul P. Patel
Department of Pharmaceutics, School of Pharmacy, RK University, Rajkot-360002, Gujarat, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 4,     Year - 2013


ABSTRACT:
Schizophrenia and schizoaffective disorder are severe and chronic psychiatric illnesses for which treatment compliance is important in the prevention of relapse. Atypical antipsychotic drugs, such as risperidone, have been found to be effective in the treatment of a range of psychiatric disorders. Sublingual tablet of oral formulations of these drugs have been developed to improve their acceptability to patients and thus improve compliance. The focus of present investigation was to improve solubility, bioavailability and to achieved rapid onset action. The solubility was improved by using solid dispersion with Beta-cyclodextrin. Sublingual tablets of risperidone were prepared by direct compression technique. Nine Formulations were formulated using 32 full factorial designs to explore the effects of sodium starch glycolate and micro crystalline cellulose (as independent variables) on Friability, Disintegration time and t90 % drug release (as dependent variables). In addition, the prepared tablets were also evaluated for weight variation, thickness, diameter, friability, content uniformity, wetting time and drug release studies. The formulation was optimized with desirable friability, disintegration time and t90 % drug release by using design expert software 8.0.6.1. Batch F2 reveals fast dissolution and disintegration rate of optimized risperidone sublingual tablet, which is prerequisite for rapid management of schizophrenia.


Cite this article:
Naimish A. Sarkhejiya, Krupraj K. Khachar, Vipul P. Patel. Formulation Development and Evaluation of Sublingual Tablet of Risperidone. Research J. Pharm. and Tech. 6(4): April 2013; Page 428-434.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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