Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Development and validation of a Rapid Stability Indicating chromatographic determination of Cilnidipine in Bulk and Dosage form.

Author(s): Mohammed M Safhi, Manohara Yagaina Nagaraj

Email(s): manohara_yn@yahoo.com

DOI: Not Available

Address: Mohammed M Safhi, Manohara Yagaina Nagaraj*
College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2013

 View HTML        View PDF

ABSTRACT:
A rapid, simple and specific reversed-phase HPLC method has been developed for estimation of Cilnidipine in Pharmaceutical Formulation. HPLC analysis was performed on a C18 column using a 80:20 (v/v) mixture of Methanol and 0.05 M Phosphate Buffer at pH 3.0 as isocratic mobile phase at a flow rate of 1 ml min-1. UV detection was carried at 254 nm. The method was validated for accuracy, precision, linearity, specificity. Validation revealed the method is specific, accurate, precise, reliable and reproducible. Good linear correlation coefficients (r2 > 0.9999) were obtained for calibration plots in the ranges tested. Limit of detection was 0.179 microgram/ml and limit of quantification was 0.544 microgram/ml. Intra and inter-day RSD of retention times and peak areas were less than 1.729% and recovery was between 99.95% and 101.09%. The established HPLC method is appropriate enabling efficient quantitative analysis of Cilnidipine in Pharmaceutical Formulation.


Keywords:

Cite this article:
Mohammed M Safhi, Manohara Yagaina Nagaraj. Development and validation of a Rapid Stability Indicating chromatographic determination of Cilnidipine in Bulk and Dosage form. Research J. Pharm. and Tech. 6(3): March 2013; Page 296-299.


Recomonded Articles:

Analytical method development and validation of ambroxol hydrochloride by UV spectroscopy and forced degradation study and detection of stability.

Author(s): M. Sumithra, P. Yuvanesh, Anamika Mistry

DOI: 10.5958/0974-360X.2016.00152.9         Access: Open Access Read More

RP-HPLC Method for Simultaneous Estimation of Albendazole and Niclosamide in Oral Suspension for Veterinary Use

Author(s): Murugan S, Upendra Janardhan CH, Niranjan Babu M

DOI: DOI: 10.5958/0974-360X.2016.00006.8         Access: Open Access Read More

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Adhesive Polymers in Fabrication of Transdermal Drug delivery

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Development of a Validated Reverse Phase Liquid Chromatographic Assay-Method for determination of Tofacitinib in pure form and in Physical Admixtures

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Taxonomical, Phytochemical and Pharmacological Reviews of Musa sapientum var. Paradisiaca.

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Analytical Method Development and Validation for Simultaneous Estimation of Montelukast and Ebastine by HPLC

Author(s): Baokar Shrikrishna, Ranpise Nisharani

DOI: 10.5958/0974-360X.2015.00001.3         Access: Open Access Read More

Method development and validation of Bronopol (Preservative) and its Stability Indicating Study by UV Spectrophotometry

Author(s): Pankaj Kapupara, Dhara Parekh, Ketan Shah

DOI: 10.5958/0974-360X.2016.00175.X         Access: Open Access Read More

Spectroscopic Estimation of Tenofovir Alafenamide, an antiretroviral drug

Author(s): Pankaj Kumar, Jane Jacob, Khadjeeth Ajina, Jazeela, Fathima

DOI: 10.5958/0974-360X.2016.00101.3         Access: Open Access Read More

An exhaustive review based on the formulation and evaluation methods behind the development of transdermal drug delivery systems

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Analytical and Bioanalytical Method for Quantification of Pure Azilsartan, Not its Salts by RP-HPLC

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Determination of Calcipotriene in Calcipotriene Cream 0.05% w/w by RP-HPLC Method Development and Validation

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Cleaning Validation Study of Amoxycillin Trihydrate

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

An overview on the established pharmaceutical aspects associated with the development of hydrogels

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Determination of Riluzole in Human Plasma by Ultra Performance Liquid Chromatography – Tandem Mass Spectrometry (UPLC – MS/MS) and its Application to a Pharmacokinetic Study

Author(s): Prathyusha Vikram, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2017.00042.7         Access: Open Access Read More

Method Development and Validation of Fingolimod in Bulk and Tablet Dosage Form by RP-HPLC

Author(s): Murugan S, Chandra Sekhar R

DOI: 10.5958/0974-360X.2017.00456.5         Access: Open Access Read More

Analytical Method Development and Validation for the Determination of Allopurinol and Alphalipoic Acid Using Reverse Phase HPLC Method in Bulk and Tablet Dosage Form

Author(s): R. Vani, B. Vijaya Kumar, G. Krishna Mohan

DOI: 10.5958/0974-360X.2015.00038.4         Access: Open Access Read More

Spectrophotometric Analysis for Estimation of Felodipine in Tablet Dosage Form by Calibration Curve Method

Author(s): Hemlata M. Nimje, Rajesh J. Oswal, Sandip S. Kshirsagar, Manoj Chavan

DOI: Not Available         Access: Open Access Read More

RP-HPLC Method for the Simultaneous Estimation and Validation of Amlodipine Besylate and Atenolol in Bulk and Tablet Dosage Form in Biorelevant Dissolution Medium (Fassif)

Author(s): Palani Shanmugasundaram, Kamarapu S. K

DOI: 10.5958/0974-360X.2017.00601.1         Access: Open Access Read More

Physical Rheological and Cell Viability Study of Some Selected Plant Polysaccharides

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Analytical Method development and Validation of Teneligliptin by RP-UFLC
A Modified Method to Determine Lipids Peroxidation in patients with HPV16 Cervicitis
Pharmacokinetic Modifications of Immediate release tablets of Raloxifene Hydrochloride by hot melt Technology
Formulation and Evaluation of Gastro Retentive Floating Tablets of Ritonavir
Evaluation of haematological changes in Entamoeba histolytica-infected rats administered with extracts of Ziziphus mauritiana leaves
Optimization of xylanase production from penicillium funiculosum using agricultural (Corn cob) waste
In vivo Study of Insulin-loaded Microemulsion Topical gel with Aloe vera for the Treatment of Dermatologic Manifestation of Diabetes
Effect of Vitamin D supplement on the risks of Cardiovascular disease in patients with type 2 diabetes in the Kurdistan Region of Iraq
Use of inhaler device in patients with Asthma or Chronic obstructive pulmonary disease: Errors and Adherence problems
Homology modeling of microbial Nattokinase enzyme, An Anti-blood clotting (Fibrinolytic) agent using computational tools
Optimization and Characterization of Lipid Based Nano Emulsion of Prednisolone Acetate for Ophthalmic Drug Delivery
Neuroprotective Potency of Tamarindus indica Seed Extract for Preventing Memory Impairment in Rat Model of Alzheimer
Preparation and Evaluation of Nifedipine solid dispersions
Evaluation of Anti-cancer, Antioxidant and Antimicrobial Activities of Alstonia scholaris L
Methanol and Ethyl Acetate Extracts of Red Fruit (Pandanus conoideus Lam.) Short-Red showed high of Phenolic and Radicals Scavenging Activities
Biological activity of Simarouba amara (Aubl.) bark
An Insilico Pharmacological Evaluation of Saraswatharishtam for Alzheimer’s disease - An Ayurvedic Formulation
Utility of Maxilla-mandibular indices for gender determination by using lateral cephalograms
The knowledge and views of Indian researchers concerning India’s current drugs and clinical trial regulations
Formulation Development and In vitro Characterization of solid lipid Nanoparticles of Felbamate

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 15177
Yesterday: 13924
Total: 3278656