Author(s): Mohammed M Safhi, Manohara Yagaina Nagaraj

Email(s): manohara_yn@yahoo.com

DOI: Not Available

Address: Mohammed M Safhi, Manohara Yagaina Nagaraj*
College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2013


ABSTRACT:
A rapid, simple and specific reversed-phase HPLC method has been developed for estimation of Cilnidipine in Pharmaceutical Formulation. HPLC analysis was performed on a C18 column using a 80:20 (v/v) mixture of Methanol and 0.05 M Phosphate Buffer at pH 3.0 as isocratic mobile phase at a flow rate of 1 ml min-1. UV detection was carried at 254 nm. The method was validated for accuracy, precision, linearity, specificity. Validation revealed the method is specific, accurate, precise, reliable and reproducible. Good linear correlation coefficients (r2 > 0.9999) were obtained for calibration plots in the ranges tested. Limit of detection was 0.179 microgram/ml and limit of quantification was 0.544 microgram/ml. Intra and inter-day RSD of retention times and peak areas were less than 1.729% and recovery was between 99.95% and 101.09%. The established HPLC method is appropriate enabling efficient quantitative analysis of Cilnidipine in Pharmaceutical Formulation.


Cite this article:
Mohammed M Safhi, Manohara Yagaina Nagaraj. Development and validation of a Rapid Stability Indicating chromatographic determination of Cilnidipine in Bulk and Dosage form. Research J. Pharm. and Tech. 6(3): March 2013; Page 296-299.

Cite(Electronic):
Mohammed M Safhi, Manohara Yagaina Nagaraj. Development and validation of a Rapid Stability Indicating chromatographic determination of Cilnidipine in Bulk and Dosage form. Research J. Pharm. and Tech. 6(3): March 2013; Page 296-299.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2013-6-3-8


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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