Author(s): Atul Ramchandra Chopade, Fahim Jehangir Sayyad

Email(s): atulrchopade@gmail.com

DOI: Not Available

Address: Atul Ramchandra Chopade* and Fahim Jehangir Sayyad
Dept. of Pharmacology and Pharmacognosy, Government College of Pharmacy, Karad, District,- Satara. 415124, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2013


ABSTRACT:
Objective: To evaluate the membrane stabilizing potential and inhibition of protein denaturation property of hydroalcoholic extract Phyllanthus fraternus Webster [PF]. Method – Hydroalcoholic extract of PF was evaluated using the human red blood cells (HRBC) membrane stabilization method as HRBC membranes are similar to lysosomal membrane components. The prevention of hypotonicity-induced HRBC membrane lysis was taken as a measure of anti-inflammatory activity of PF extract. While the extract was also incubated with egg albumin and subjected to determination of absorbance and viscosity to assess the anti-inflammatory property. Results- The hydroalcoholic extract of PF in concentration of 25-800 microgram/ml showed a concentration dependent inhibition of haemolysis of erythrocytes induced by hypotonic solution. The hydroalcoholic extract of PF also showed a concentration dependent inhibition of protein (albumin) denaturation with IC50 of 52 microgramml. Conclusion- From the study it can be postulated that the anti-inflammatory activity of Phyllanthus fraternus Webster could be due to its membrane stabilizing action and inhibition of protein denaturation.


Cite this article:
Atul Ramchandra Chopade, Fahim Jehangir Sayyad. Evaluation of membrane stabilizing and inhibition of protein denaturation activity of Phyllanthus fraternus Webster. Research J. Pharm. and Tech. 6(3): March 2013; Page 251-254.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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