Author(s): Somsubhra Ghosh, Sowjanya Bomma, V. Laxmi Prasanna, S. Vidyadhar, David Banji, Subhadip Roy

Email(s): som_subhra_ghosh@yahoo.co.in

DOI: Not Available

Address: Somsubhra Ghosh1*, Sowjanya Bomma1, V. Laxmi Prasanna1, S. Vidyadhar1, David Banji1, Subhadip Roy2
1Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, India, 508001.
2 Mylan Laboratories Ltd, Hyderabad, Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2013


ABSTRACT:
A new simple, accurate, rapid and precise isocratic High Performance Liquid Chromatographic (HPLC) method was developed and validated for the determination of Rilpivirine in bulk drug & its tablet doses form. The Method employs Waters HPLC system on C8 Column (4.6 x 250 mm, 5 µm) and flow rate of 1 ml/min with a load of 10µl. The Detection was carried out at 282 nm. mobile phase used as Acetonitrile and Phosphate buffer was used as mobile phase in the composition of 60:40, phosphate buffer adjusted the pH to 3.5, within a short runtime of 6 min. The retention times of Rilpivirine 2.75 min. The method was validated according to the regulatory guidelines with respect to specificity, precision, accuracy, linearity and robustness etc.


Cite this article:
Somsubhra Ghosh, Sowjanya Bomma, V. Laxmi Prasanna, S. Vidyadhar, David Banji, Subhadip Roy. Method development and validation of Rilpivirine in bulk and Tablet doses form by RP-HPLC method. Research J. Pharm. and Tech. 6(3): March 2013; Page 240-243.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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