Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Microemulsion based vaginal gel of antifungal drug: design, development and evaluation

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

Email(s): kumkumsarangdevot@gmail.com

DOI: Not Available

Address: Kumkum Sarangdevot1*, Bhawani Singh Sonigara2, Amul Mishra2, K. C. Gupta1, Surbhi Sharma1
1Pacific College of Pharmacy, Udaipur (Rajasthan) - 313003 INDIA
2B.N. College of Pharmacy, Udaipur (Rajasthan) – 313002 INDIA
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2013

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ABSTRACT:
The purpose of the present study was to develop and evaluate microemulsion based gel for the delivery of fluconazole (FLZ). The solubility of FLZ in oils and surfactants was evaluated to identify the components of the microemulsion. Microemulsion base was prepared by using iso propyl myristate as oil phase, tween 80 as surfactant and propylene glycol as co-surfactant. Microemulsion existence region was determined by using the pseudo-ternary phase diagrams for different formulations. Microemulsion formulations were evaluated for pH, viscosity, conductivity and dilutability. Globule size of drug loaded microemulsions was ranges from 29.4 nm to 21.4 nm. Polydispersity index of microemulsion was ranges from 0.555 to 0.135. Zeta potential of selected batches was found to be zero which show neutral charge as the microemulsion formulations consisted of nonionic surfactant. Various gelling agents were evaluated for their potential to gel the FLZ microemulsion without affecting its structure. FLZ microemulsion based gel (MBG-FLZ) was characterized for viscosity, transmission electron microscopy and spreadability. In-vitro permeation of FLZ from the gel was evaluated using Franz diffusion cells mounted with rat skin. The results indicated that the MBG-FLZ would be a promising tool for enhancing the percutaneous delivery of fluconazole.


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Cite this article:
Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma. Microemulsion based vaginal gel of antifungal drug: design, development and evaluation. Research J. Pharm. and Tech. 6(2): Feb. 2013; Page 166-173.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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