Author(s): Kiran Deshpande, Pranjali Ranaware, A. R. Madgulkar, M.C. Damle

Email(s): mcdamle@rediffmail.com

DOI: Not Available

Address: Kiran Deshpande, Pranjali Ranaware, A. R. Madgulkar, M.C. Damle*
Department of Pharmaceutical Chemistry, AISSMS College of Pharmacy, Kennedy road, Near R.T.O
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2013


ABSTRACT:
Repaglinide is a widely used meglitinide class drug to treat diabetes. The current study describes degradation as per ICH guidelines (hydrolysis, photolysis, dry heat and oxidation) and optimized assay method. A simple stability indicating method has been developed for Repaglinide in bulk drug. The peak purity of the drug was observed. For HPTLC study Aluminium plates precoated with Silica Gel 60 F254 was the stationary phase and mobile phase consisted of methanol: toluene (2:8 ) and quantitation was done at the wavelength 242nm. The method was found to be simple, specific, precise and stability indicating.


Cite this article:
Kiran Deshpande, Pranjali Ranaware, A. R. Madgulkar, M.C. Damle. Development and Validation of Stability Indicating HPTLC Method for Determination of Repaglinide. Research J. Pharm. and Tech. 6(2): Feb. 2013; Page 158-161.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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