Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Formulation development and evaluation of semisolid preparation of antifungal drug: Itraconazole

Author(s): Samip Shah, T. Y. Pasha, Dipti Desai, Anil Bhandari

Email(s): samipshah2008@yahoo.com

DOI: Not Available

Address: Samip Shah1*, Dr. T. Y. Pasha2, Dipti Desai2, Dr. Anil Bhandari1
1Jodhpur National University, Jodhpur, Rajasthan, India
2Pioneer Pharmacy Degree College, Vaodara, India
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2013

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ABSTRACT:
Itraconazole (ITZ) is a synthetic triazole antifungal agent that is active against a broad spectrum of fungal species and effective for the treatment of both systemic fungal infections and superficial mycoses. Sporanox® capsule, oral solution and injection (Janssen Pharmaceutical) are the only commercialized product of itraconazole. The absolute bioavailability of oral ITZ is 55% (±15%) and reduced by 40% when it is administered under fasting conditions. In the present work various semisolid formulations of ITZ were developed for topical use with the objective to improve its therapeutic efficacy, patient compliance and to reduce the frequency of dosing and side effects, as well as to avoid its extensive first pass metabolism. Total six semisolid formulations belonging to ointment, cream and gel were prepared and evaluated for various physicochemical parameters like pH, drug content, rheological properties, in vitro drug release and ex vivo drug permeation. The selected formulation from the results of above mentioned evaluation tests was further subjected to skin irritation test on rabbit, antifungal activities and accelerated stability study. It was observed that pH and drug content of all formulations were in limit. Formulation F4 showed the highest in vitro drug release and ex vivo permeation among all the formulations. The in vitro release from all formulations followed Higuchi's diffusion mechanism. No irritation was observed by skin irritation test. It can be concluded that HPMC gel containing ITZ can extend the release of drug for longer period and has wider prospect for topical preparations.


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Cite this article:
Samip Shah, T. Y. Pasha, Dipti Desai, Anil Bhandari. Formulation development and evaluation of semisolid preparation of antifungal drug: Itraconazole. Research J. Pharm. and Tech. 6(2): Feb. 2013; Page 152-157.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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