Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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L-Arginase: a Medically Important Enzyme

Author(s): Kuldeep Kumar, Neelam Verma

Email(s): kuldeepbio@gmail.com

DOI: Not Available

Address: Kuldeep Kumar1* and Neelam Verma2
1Department of Biotechnology, M.M. Modi College, Patiala-147 001 Punjab (India)
2Department of Biotechnology, Punjabi University, Patiala-147 002 Punjab (India)
*Corresponding Author

Published In:   Volume - 6,      Issue - 12,     Year - 2013

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ABSTRACT:
L-arginase also referred to as L-arginine amidinohydrolase (EC.3.5.3.1) catalyzes the hydrolysis of L-arginine into L-ornithine and urea which is the last step of urea cycle in liver of ureotelic species. This enzyme exists in two forms. The first one is arginase-1, is found in liver cells and second one is arginase-2 which is a mitochondrial enzyme that occurs mainly in extra hepatic tissues including kidney, brain and skeletal muscle. L-arginase consists of three tetramers. The present article comprises information on the enzyme L-arginase, which is used in the treatment of cancer. It is isolated from variety of sources such as bacterial cells, yeast cells, fungal cells and plant cells. The present review has discussed about the production of enzyme from different sources, method of assay, purification and characterization of enzyme including the structural information of L- arginase.


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Cite this article:
Kuldeep Kumar, Neelam Verma. L-Arginase: a Medically Important Enzyme. Research J. Pharm. and Tech. 6(12): Dec. 2013; Page 1430-1438.


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DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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