Author(s): G. Subba Rao, T.E.G.K. Murthy

Email(s): subbarao_gutta@yahoo.co.in

DOI: Not Available

Address: G. Subba Rao1*, T.E.G.K. Murthy2
1Department of Pharmaceutics, Sri Siddhartha Pharmacy College, Nuzvid, Andhra Pradesh, India-521201
2Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India -522101
*Corresponding Author

Published In:   Volume - 6,      Issue - 11,     Year - 2013


ABSTRACT:
The objective of the study was to develop mucoadhesive buccal tablet of carvedilol. Tablets of carvedilol were prepared by direct compression method using mucoadhesive polymers like sodium alginate, Gum karaya, pectin and Gum kondagogu in different ratios. Buccal tablets were evaluated by different methods for parameters such as hardness, weight uniformity, drug content uniformity, swelling index, surface pH, ex vivo mucoadhesive strength, ex vivo residence time, in vitro drug release, ex vivo drug permeation and stability studies. The tablets were evaluated for in vitro release for 8.5 hr in standard dissolution apparatus. Mucoadhesion strength was increased with increase in the concentration of gum kondagogu. In order to determine the mode of release, the data was subjected to Zero order, first order, Higuchi and Peppas diffusion model. Short-term stability studies on the promising formulations indicated that there were no significant changes in drug content, ex-vivo mucoadhesive strength and in vitro dissolution characteristics. IR, DSC, and XRD studies indicated that there were no drug-excipient interactions. The prepared buccal tablets of carvedilol could stay in the buccal for a longer period of time, which indicate a potential use of mucoadhesive tablets of carvedilol for treating Hypertensive patients.


Cite this article:
G. Subba Rao, T.E.G.K. Murthy. Formulation and Evaluation of Buccal Tablets of Carvedilol. Research J. Pharm. and Tech. 6(11): November 2013; Page 1207-1216.


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