Author(s): Vijaya Kumar S., Dhirendra B. Sanghai, Mallikarjuna Rao C., Shreedhara C. S.

Email(s): css.shim@manipal.edu

DOI: Not Available

Address: Vijaya Kumar S.1, Dhirendra B. Sanghai1, Mallikarjuna Rao C.2, Shreedhara C. S. 1*
1Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576104, Karnataka, India.
2Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal-576104, Karnataka, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 11,     Year - 2013


ABSTRACT:
Melia azedarach Linn, a deciduous tree belonging to Family Meliaceae, has been used traditionally for variety of ailments. Antioxidant and antihyperlipidemic activities of the extracts of leaves of Melia azedarach were studied by in vitro antioxidant assays and in vivo effects by Triton-WR 139 induced hyperlipidaemic model and high fat diet induced hyperlipidaemia model in Wistar albino rats. The phenolic and flavonoid content was also estimated. In Triton induced hyperlipidaemic model and also in high fat induced hyperlipidaemic model, aqueous and methanolic extracts has shown significant lipid lowering activity. In antioxidant activity study, ethyl acetate extract showed better IC50 values in the DPPH and ABTS model, whereas, in o-phenanthroline assay, chloroform extract has shown better IC50 value. Phenolic content in aqueous extract was found to be more, while flavonoid content in ethyl acetate extract


Cite this article:
Vijaya Kumar S., Dhirendra B. Sanghai, Mallikarjuna Rao C., Shreedhara C. S. Antioxidant and antihyperlipidemic activity of Melia azedarach Linn. extracts in rats. Research J. Pharm. and Tech. 6(11): November 2013; Page 1195-1199.


Recomonded Articles:

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Praveen D, Ranadheer Chowdary P, Gandikota Thanmayi, Gangabathina Poojitha, Vijey Aanandhi M

DOI: 0.5958/0974-360X.2016.00047.0         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Josephin Nerling Rashida G., T. Venkatarathnakumar, R. Gowri, Ajithadhas Aruna

DOI: Not Available         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): J.S. Vaghela, S.S. Sisodia

DOI: Not Available         Access: Open Access Read More

Author(s): U.S MahadevaRao, Khamsah Suryati Mohd, Siti Zulaikha Bt Abd Halim, Masitah Bt Khamis

DOI: Not Available         Access: Open Access Read More

Author(s): Didi Chinnu Raju, T Diana Victoria, Nancy Biji, Gandra Nikitha

DOI: 10.5958/0974-360X.2015.00234.6         Access: Open Access Read More

Author(s): Ranju Pal, Kundlik Girhepunje, Nidhi Shrivastava, Mohammed Misbah Hussain, Thirumoorthy N

DOI: Not Available         Access: Open Access Read More

Author(s): Gunde MC, Suruse PB, Amnerkar ND, Lohe RW, Godbole MD, Kale MK, Pathak AK

DOI:         Access: Open Access Read More

Author(s): T. Sheela Rani, V. Gopal, S. Seethalakshmi, K. Chitra

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags