Microbubbles designate air or gas filled microspheres suspended in a liquid carrier phase. The liquid carrier phase contains surface active agents which control the surface properties and stability of the bubble. The new innovative technique that uses ultrasound and drug-laden “microbubbles” to deliver concentrated chemotherapy drugs to the inner lining of blood vessels. Ultrasound-microbubbles technique is a novel method for noninvasive delivering of drug and genes to different tissues. In this method the drug is carried until a particular area of interest is reach, and then with the help of ultrasound the microbubbles were burst, causing site-specific deliverance of the bioactive materials. In the medical field these microbubbles are used as diagnostic aids with ultrasound for molecular imaging of various organs and even tumors. The microbubbles containing drug generally have an average size less than that of RBCs, i.e. they are penetrate easily even into the small blood capillaries. After penetration they release genes and drugs under the action of ultrasound field. Today many of the physicians use to prefer imaging with microbubble ultrasound as a contrast agent in comparison with other diagnostic techniques due to their low cost and rapidity. The microbubbles filled with gas, such as air or perflurocarbon vacillate and vibrate when a sonic energy field is apply and it may reflect ultrasound waves. In practice, as the gas bubbles in liquid has less stability and it dissolve quickly; microbubbles must be encapsulated with a solid shell. The solid shell is made from a lipid or a protein. This review focuses on the properties of microbubbles that give them therapeutic importance and important application in cancer therapy, right from diagnosis to treatment in different types of cancer.
Cite this article:
P. U. Kokulwar, K. G. Lakhane, S. S. Mitkare. Microbubble Ultrasound: A Novel Approach in Cancer Therapy. Research J. Pharm. and Tech. 6(11): November 2013; Page 1279-1284.