Hamed Mohsen, Haddad Shaden, AL Quobili Faiza, Hammoud Taghrid
Hamed Mohsen1*, Haddad Shaden1, AL Quobili Faiza1, Hammoud Taghrid2
1Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria.
2Department of Physiology and Pharmacology, Faculty of Medicine, Damascus University, Damascus, Syria.
Volume - 6,
Issue - 10,
Year - 2013
We aim at exploring the probable association among obesity, leptin and insulin resistance in type 2 diabetes mellitus.126 patients (62 women and 64 men) with T2DM, and 74 healthy controls (42 women and 32 men). Type 2 diabetes mellitus patients were recruited from several medical centers in Damascus. Obesity factors (body mass index BMI, waist circumference, waist to hip ratio WHR), insulin resistance (HOMA-IR and fasting insulin), fasting Glucose and leptin were measured.
Serum leptin levels were significantly higher in type2 diabetic patient group in both sexes compared with control group, and positively correlated with body mass index, waist circumference, waist to hip ratio, HOMA-IR, insulin, in both sexes. Statistically, there was no significant correlation between serum leptin and glucose in both sexes.
Cite this article:
Hamed Mohsen, Haddad Shaden, AL Quobili Faiza, Hammoud Taghrid. Correlation of serum leptin levels with insulin resistance in Syrian obese patients with type 2 diabetes mellitus. Research J. Pharm. and Tech. 6(10): October 2013; Page 1149-1151.